Tempus Labs Research Scientist Interview Questions + Guide in 2025

Tempus Labs is at the forefront of precision medicine, leveraging advanced technology to provide real-time, actionable insights to enhance clinical care for patients.

The Research Scientist role at Tempus Labs is pivotal in supporting the Biological Modeling team, focusing on Organoid Based Screening. As a Research Scientist, you will be responsible for conducting high-throughput gene-editing, imaging, and protein detection workflows, while collaborating in a multidisciplinary environment. Key responsibilities include designing and executing experiments involving human tumor models, analyzing large datasets, and utilizing automated liquid handling systems. The ideal candidate will possess a Ph.D. in oncology or molecular systems biology, along with industry or post-doctoral experience. Proficiency in R and Python, strong knowledge of molecular gene editing, and familiarity with sequencing studies are essential. A successful candidate embodies a passion for advancing healthcare and demonstrates effective communication skills to convey results to both internal teams and external partners.

This guide aims to equip you with the necessary insights and preparation tips for succeeding in your interview at Tempus Labs, ensuring you align your skills and experiences with their mission and values throughout the process.

The interview process for a Research Scientist at Tempus Labs is structured to assess both technical expertise and cultural fit within the organization. It typically unfolds in several stages, each designed to evaluate different aspects of a candidate's qualifications and experience.

1. Initial Recruiter Screen

The process begins with a phone call from a recruiter, lasting about 30 minutes. During this conversation, the recruiter will discuss your background, the role, and the company culture. This is an opportunity for you to express your interest in precision medicine and how your experience aligns with Tempus' mission.

2. Technical Assessment

Following the initial screen, candidates are often required to complete a take-home coding or technical assignment. This assessment may involve analyzing a dataset relevant to the role, such as gene expression data, and developing models or workflows that demonstrate your proficiency in R or Python. The goal is to evaluate your technical skills and ability to handle real-world data challenges.

3. Video Interviews

Candidates who successfully complete the technical assessment will move on to a series of video interviews. These typically include a behavioral interview with team members, where you will be asked about your past experiences, problem-solving approaches, and how you work in a collaborative environment. Expect scenario-based questions that assess your ability to communicate results and work within multidisciplinary teams.

4. Onsite Interview

The final stage usually consists of an onsite interview, which may be conducted virtually. This session can last up to three hours and includes multiple rounds with different team members. You may face questions related to system design, gene-editing workflows, and high-throughput data analysis. Additionally, there will be discussions about your take-home assignment, where interviewers will probe into your coding style and decision-making processes.

5. Final Evaluation

After the onsite interviews, candidates can expect a follow-up from the recruiter regarding feedback and next steps. This stage may also include a background check and verification of previous employment and education.

As you prepare for your interview, it's essential to be ready for a range of questions that will test your technical knowledge and interpersonal skills. Here are some of the types of questions you might encounter during the interview process.

Here are some tips to help you excel in your interview.

Understand the Company’s Mission and Values

Tempus Labs is deeply committed to advancing precision medicine and improving healthcare through innovative technology. Familiarize yourself with their mission, recent advancements, and how they leverage AI to provide actionable insights in clinical care. This knowledge will not only help you answer questions more effectively but also demonstrate your genuine interest in the company and its goals.

Prepare for a Multi-Stage Interview Process

The interview process at Tempus typically involves multiple stages, including a recruiter screen, a take-home assignment, and several rounds of interviews with team members. Be prepared to discuss your background and experience in detail, as well as to showcase your technical skills through coding challenges or project discussions. Make sure to allocate enough time to complete the take-home assignment thoroughly, as it is a critical part of the evaluation process.

Emphasize Your Technical Skills

Given the role's focus on molecular gene editing, imaging, and data analysis, be ready to discuss your proficiency in relevant technical skills, particularly in R and Python. Brush up on your knowledge of high-throughput workflows, sequencing studies, and data visualization techniques. You may also be asked to explain your experience with automated liquid handlers and how you have coordinated complex experimental workflows in previous roles.

Showcase Your Collaborative Spirit

Tempus values teamwork and collaboration across multidisciplinary teams. Be prepared to share examples of how you have successfully worked in a team environment, particularly in scientific settings. Highlight your ability to communicate results effectively, both internally and to external partners, as this is crucial for the role.

Be Ready for Behavioral Questions

Expect a mix of behavioral and technical questions during your interviews. Prepare to discuss your strengths, weaknesses, and how you handle challenges in a fast-paced environment. Use the STAR (Situation, Task, Action, Result) method to structure your responses, ensuring you provide clear and concise examples that demonstrate your problem-solving abilities and adaptability.

Follow Up and Seek Feedback

After your interviews, don’t hesitate to follow up with your recruiter or interviewers to express your appreciation for the opportunity and to inquire about the next steps. However, be aware that some candidates have reported a lack of communication post-interview, so managing your expectations is important. If you receive feedback, use it constructively to improve your future interviews.

Trust Your Instincts

While preparing for the interview, also consider the company culture and how it aligns with your values and work style. Some candidates have reported mixed experiences regarding the interview process and organizational culture at Tempus. Trust your instincts about whether this is the right fit for you, and don’t hesitate to explore other opportunities if you feel uncertain.

By following these tips and preparing thoroughly, you can position yourself as a strong candidate for the Research Scientist role at Tempus Labs. Good luck!

In this section, we’ll review the various interview questions that might be asked during a Research Scientist interview at Tempus Labs. The interview process will likely assess your technical expertise in molecular biology, gene editing, and data analysis, as well as your ability to work collaboratively in a fast-paced environment. Be prepared to discuss your previous experiences, technical skills, and how you approach problem-solving in a research context.

Technical Expertise

1. Can you explain your experience with gene editing techniques and how you have applied them in your research?

This question aims to gauge your familiarity with gene editing technologies and their practical applications.

How to Answer

Discuss specific gene editing techniques you have used, such as CRISPR or TALENs, and provide examples of how you implemented these techniques in your research projects.

Example

“I have extensive experience with CRISPR-Cas9 gene editing, which I utilized in my post-doctoral research to create knockout models for studying gene function in cancer. This approach allowed us to identify critical pathways involved in tumor progression, leading to potential therapeutic targets.”

2. Describe your experience with high-throughput screening and the workflows you have developed.

This question assesses your ability to design and execute complex experimental workflows.

How to Answer

Highlight specific high-throughput screening methods you have employed, detailing the steps involved in the workflow and any automation tools you used.

Example

“In my previous role, I developed a high-throughput screening workflow for evaluating small molecule inhibitors on organoid cultures. I utilized automated liquid handling systems to streamline the process, which significantly increased our throughput and data accuracy.”

3. How do you approach data analysis for large datasets generated from sequencing studies?

This question evaluates your analytical skills and familiarity with data processing tools.

How to Answer

Discuss the software and programming languages you use for data analysis, as well as your approach to visualizing and interpreting the results.

Example

“I typically use R for analyzing sequencing data, employing packages like DESeq2 for differential expression analysis. I also develop custom scripts to visualize the data, which helps in identifying significant patterns and trends in gene expression.”

4. Can you describe a challenging problem you faced in your research and how you overcame it?

This question is designed to assess your problem-solving skills and resilience in a research setting.

How to Answer

Provide a specific example of a challenge, the steps you took to address it, and the outcome of your efforts.

Example

“During a project involving 3D tissue models, we encountered issues with cell viability. I collaborated with my team to optimize the culture conditions and introduced a new media formulation, which improved cell survival rates and allowed us to proceed with our experiments successfully.”

5. What experience do you have with microscopy techniques, particularly fluorescent imaging?

This question assesses your technical skills in imaging and analysis.

How to Answer

Discuss your experience with different microscopy techniques, focusing on how you have used them in your research.

Example

“I have extensive experience with both brightfield and fluorescent microscopy. In my last project, I used fluorescent imaging to visualize protein localization in organoid cultures, which provided insights into cellular responses to treatment.”

Behavioral and Teamwork

1. How do you prioritize tasks when working on multiple projects simultaneously?

This question evaluates your time management and organizational skills.

How to Answer

Explain your approach to prioritizing tasks and managing deadlines in a research environment.

Example

“I prioritize tasks based on project deadlines and the potential impact of the results. I use project management tools to keep track of progress and regularly communicate with my team to ensure alignment on priorities.”

2. Describe a time when you had to communicate complex scientific concepts to a non-technical audience.

This question assesses your communication skills and ability to convey information effectively.

How to Answer

Provide an example of a situation where you successfully communicated complex information, focusing on your approach and the outcome.

Example

“I once presented our research findings to a group of investors who had limited scientific backgrounds. I focused on the implications of our work in layman's terms, using visuals to illustrate key points, which helped them understand the significance of our research and secure funding.”

3. How do you handle conflicts within a team?

This question evaluates your interpersonal skills and ability to work collaboratively.

How to Answer

Discuss your approach to resolving conflicts and maintaining a positive team dynamic.

Example

“When conflicts arise, I believe in addressing them directly and constructively. I encourage open dialogue to understand different perspectives and work towards a solution that aligns with our common goals.”

4. What motivates you to work in the field of precision medicine?

This question assesses your passion and commitment to the field.

How to Answer

Share your motivations and what drives you to contribute to advancements in precision medicine.

Example

“I am deeply motivated by the potential of precision medicine to transform patient care. The ability to tailor treatments based on individual genetic profiles excites me, and I am committed to contributing to research that can lead to more effective therapies.”

5. Why do you want to work at Tempus Labs?

This question gauges your interest in the company and alignment with its mission.

How to Answer

Discuss what specifically attracts you to Tempus Labs and how your values align with the company’s goals.

Example

“I am drawn to Tempus Labs because of its commitment to leveraging data and technology to improve patient outcomes. I admire the innovative approach to precision medicine and believe my background in molecular biology and experience with organoid models would allow me to contribute meaningfully to your team.”