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Precision medicine group Interview Questions

formed in 2012, precision medicine group is a specialized services company supporting next-generation approaches to drug development and commercialization. precision provides an integrated infrastructure that supports pharmaceutical and life sciences companies as they develop new products in the age of precision medicine. the company is headquartered in bethesda, md., with offices throughout the us, canada, and europe. for more information, visit precisionmedicinegrp.com.

formed in 2012, precision medicine group is a specialized services company supporting next-generation approaches to drug development and commercialization. precision provides an integrated infrastructure that supports pharmaceutical and life sciences companies as they develop new products in the age of precision medicine. the company is headquartered in bethesda, md., with offices throughout the us, canada, and europe. for more information, visit precisionmedicinegrp.com.

Overview

Precision medicine group Interview Guides

Machine Learning

RMS Error

Missing Housing Data

What are the logistic and softmax functions? What is the difference between the two?

Softmax vs Logistic

How to model merchant acquisition in a new market?

Merchant Acquisition

Random Forest Explanation

Data Structures & Algorithms

Given an integer N, write a function that returns all of the prime numbers up to N

Prime to N

Moving Window

Given a json string with nested objects, write a function that flattens all the objects to a single key-value dictionary.

Flatten JSON

String Mapping

Given a list of strings, write a function that returns the longest common prefix

Common Prefix

Select the 2nd highest salary in the engineering department

2nd Highest Salary

Last Transaction

Write a query to get the number of friends of a user that like a specific page

Liked Pages

Cumulative Distribution

Given a users table, write a query to get the cumulative number of new users added by the day, with the total reset every month. 

Cumulative Reset

Analytics

How would you measure the success of an online marketplace introducing an audio chat feature given a dataset of their usage?

Audio Chat Success

How would you analyze the dataset to understand exactly where the revenue loss is occurring?

Evaluating Revenue Decline

Describing a data project and its challenges

Hurdles In Data Projects

Strategically resolving misaligned expectations with stakeholders for a successful project outcome

Stakeholder Communication

How to present complex data insights with clarity and adaptability tailored to a specific audience

Presentations and Insights

Business Case

Licensing Valuation

Delivery Fees

How to boost presence in high-demand city areas

Incentive Scheme

Decreasing Ride Costs

Vision Setting and Execution Strategy

Challenge

When an interviewer asks a question along the lines of:

<ul>
<li>What would your current manager say about you? What constructive criticisms might he give?</li>
<li>What are your three biggest strengths and weaknesses you have identified in yourself?</li>
</ul>

How would you respond?

When asked about your strengths in an interview, what is an effective way to respond?

When asked about your strengths in an interview, what is an effective way to respond?

Your Strengths and Weaknesses I

Which of the following is an acceptable strategy when discussing weaknesses in an interview?

Which of the following is an acceptable strategy when discussing weaknesses in an interview?

Your Strengths and Weaknesses II

What do you tell an interviewer when they ask you what your strengths and weaknesses are?

Your Strengths and Weaknesses

Brainteasers

When an interviewer asks you a question along the lines of:

<ul>
<li>Why did you apply to our company?</li>
<li>What are you looking for in your next job?</li>
<li>What makes you a good fit for our company?</li>
</ul>

How should you respond?

When asked 'What are you looking for in your next job?' in an interview, how can you tie the company's employee benefits into your response?

When asked 'What are you looking for in your next job?' in an interview, how can you tie the company's employee benefits into your response?

Why Do You Want to Work With Us I

How can company values be used effectively in an interview when asked 'What makes you a good fit for our company?'

How can company values be used effectively in an interview when asked 'What makes you a good fit for our company?'

Why Do You Want to Work With Us II

When responding to the question 'Why did you apply to our company?' during an interview, what aspect should you highlight?

When responding to the question 'Why did you apply to our company?' during an interview, what aspect should you highlight?

Why Do You Want to Work With Us III

How would you answer when an Interviewer asks why you applied to their company?

Why Do You Want to Work With Us

Describe a data project you worked on. What were some of the challenges you faced?

How would you explain what a p-value is to someone who is not technical?

What does a p-value in a statistical test represent?

What does a p-value in a statistical test represent?

P-value to a Layman I

In a statistical test, how does a low p-value (less than 0.05) influence our decision about the null hypothesis?

In a statistical test, how does a low p-value (less than 0.05) influence our decision about the null hypothesis?

P-value to a Layman II

P-value to a Layman

Statistics

Let’s say that you’re training a classification model.

How would you combat overfitting when building tree-based models?

Let's say that you're training a classification model.   How would you combat overfitting when building tree-based models?

Overfit Avoidance

How would you handle the data preparation for building a machine learning model using imbalanced data?

Addressing imbalanced data in machine learning through carefully prepared techniques.

Data Preparation for Imbalanced Data

Talk about a time when you had trouble communicating with stakeholders. How were you able to overcome it?

Given a string, write a function to determine if it is palindrome or not.

Note: A palindrome is a word/string that is read the same way forward as it is backward, e.g. <code>&#39;reviver&#39;</code>, <code>&#39;madam&#39;</code>, <code>&#39;deified&#39;</code> and <code>&#39;civic&#39;</code> are all palindromes, while <code>&#39;tree&#39;</code>, <code>&#39;music&#39;</code> and <code>&#39;person&#39;</code> are not palindromes.

Example:

Input:

<pre tabindex="0" class="chroma"><code>word1 = &#34;tree&#34;
word2 = &#34;radar&#34;
</code></pre>

Output:

<pre tabindex="0" class="chroma"><code>def is_palindrome(word1) -&gt; False
def is_palindrome(word2) -&gt; True
</code></pre>

Given a string, write a function to determine if it is palindrome or not.

String Palindromes

Write a SQL query to select the 2nd highest salary in the engineering department.

Note: If more than one person shares the highest salary, the query should select the next highest salary.

Example:

Input:

<code>employees</code> table

<table>
<thead>
<tr>
<th>Column</th>
<th>Type</th>
</tr>
</thead>

<tbody>
<tr>
<td><code>id</code></td>
<td>INTEGER</td>
</tr>

<tr>
<td><code>first_name</code></td>
<td>VARCHAR</td>
</tr>

<tr>
<td><code>last_name</code></td>
<td>VARCHAR</td>
</tr>

<tr>
<td><code>salary</code></td>
<td>INTEGER</td>
</tr>

<tr>
<td><code>department_id</code></td>
<td>INTEGER</td>
</tr>
</tbody>
</table>
<code>departments</code> table

<table>
<thead>
<tr>
<th>Column</th>
<th>Type</th>
</tr>
</thead>

<tbody>
<tr>
<td><code>id</code></td>
<td>INTEGER</td>
</tr>

<tr>
<td><code>name</code></td>
<td>VARCHAR</td>
</tr>
</tbody>
</table>
Output:

<table>
<thead>
<tr>
<th>Column</th>
<th>Type</th>
</tr>
</thead>

<tbody>
<tr>
<td><code>salary</code></td>
<td>INTEGER</td>
</tr>
</tbody>
</table>

Imagine you are asked to build a machine learning model to decide new loan approvals for a
financial firm. You ask the data department in the company for a subset of data to get started
working on the problem. The data includes different features about applicants such as age,
occupation, zip code, height, number of children, favorite color, etc. You decide to build
multiple machine learning models to test out different ideas before settling on the best one.

How would you explain the bias-variance tradeoff with regards to
building and choosing a model to use?

Bias vs. Variance Tradeoff

Explain the difference between the XGBoost and random forest algorithms and give an example where you would use one over the other.

Why might a data scientist choose to use XGBoost instead of Random Forest for a particular machine learning task?

Why might a data scientist choose to use XGBoost instead of Random Forest for a particular machine learning task?

XGBoost vs Random Forest: Choice

Xgboost vs Random Forest

How does random forest generate the forest? Additionally, why would we use it over other algorithms such as logistic regression?

What happens when you average the output on multiple decision trees?

What happens when you average the output on multiple decision trees?

Average Trees

Tell me about a project in which you had to clean and organize a large dataset.

Describing a real-world data cleaning and organization project

Data Cleaning Experiences

Data Pipelines

Let’s say we want to launch a re-design of a landing page to improve the click-through rate. We can do this by implementing an AB test.
Given that we launch an AB test, how would you infer if the results of the click-through rate were statistically significant or not?

How can you accurately conclude if the results of an A/B test, conducted to evaluate the effectiveness of a landing page redesign, are statistically significant?

How can you accurately conclude if the results of an A/B test, conducted to evaluate the effectiveness of a landing page redesign, are statistically significant?

Statistically Significant Test

Precisely ascertain whether the outcomes of an A/B test, executed to assess the impact of a landing page redesign, exhibit statistical significance.

A/B Testing

Let’s say you work at Allstate. Allstate is running <code>N</code> online ads right now. The table <code>ads</code> contains all those ads, ranked by popularity via the <code>id</code> column (e.g., the entry with <code>id = 1</code> is the most popular, etc.).

Create a subquery or common table expression named <code>top_ads</code> containing the top 3 ads (by popularity) and return the number of rows that would result from the following operations

<ol>
<li><code>ads INNER JOIN top_ads</code></li>
<li><code>ads LEFT JOIN top_ads</code></li>
<li><code>ads RIGHT JOIN top_ads</code></li>
<li><code>ads CROSS JOIN top_ads</code></li>
</ol>

Note: Please make the <code>join_type</code> column in your output have the values <code>inner_join</code>, <code>left_join</code>, etc. for each of their respective join types

Note: Please return only one query with each number in a different row

Example:

Input:

<table>
<thead>
<tr>
<th>Column</th>
<th>Type</th>
</tr>
</thead>

<tbody>
<tr>
<td><code>id</code></td>
<td>INTEGER</td>
</tr>

<tr>
<td><code>name</code></td>
<td>VARCHAR</td>
</tr>
</tbody>
</table>
Output:

<table>
<thead>
<tr>
<th>Column</th>
<th>Type</th>
</tr>
</thead>

<tbody>
<tr>
<td><code>join_type</code></td>
<td>VARCHAR</td>
</tr>

<tr>
<td><code>number_of_rows</code></td>
<td>INTEGER</td>
</tr>
</tbody>
</table>

Size of Joins

Given an integer <code>N</code>, write a function that returns a list of all of the prime numbers up to <code>N</code>.

Note: Return an empty list there are no prime numbers less than or equal to <code>N</code>.

Example:

Input:

<pre tabindex="0" class="chroma"><code>N = 3
</code></pre>

Output:

<pre tabindex="0" class="chroma"><code>def prime_numbers(N) -&gt; [2,3]
</code></pre>

Regularization and cross-validation are two common techniques used to improve the performance of machine learning algorithms.

When should you use one versus the other?

Given the choices below, which one is an example of a scenario where we should be using regularization?

Given the choices below, which one is an example of a scenario where we should be using regularization?

Regularization Example

Regularization and Validation

How would you convey insights and the methods you use to a non-technical audience?

Making data-driven insights actionable for those without technical expertise

Simple Explanations

What’s the relationship between PCA and K-means clustering?

What does the variable “k” in k-means clustering refer to?

What does the variable "k" in k-means clustering refer to?

Input of K-means

PCA and K-Means

Let’s say you’re a data engineer at Fidelity Investments, and you’re running a SQL query on a cloud-based data warehouse. All cluster resources and network health metrics look normal, but the query is still taking over 10 minutes to complete.

How would you go about diagnosing and improving the performance of this query?

How would you diagnose and speed up a slow SQL query when system metrics look healthy?

Slow SQL Query

Query Optimization

Describe a time when you had to define a long-term vision for a project or team and move it from concept to reality.

Interviews for leadership or senior technical roles look for more than just “finishing a project.” Your answer should specifically address:

<ol>
<li>The “Why”: What data or organizational gap necessitated this vision?</li>
<li>The Framework: How did you translate a high-level goal into a roadmap?</li>
<li>The Friction: How did you handle stakeholders or team members who were skeptical of the new direction?</li>
</ol>

We want to build a model to predict housing prices in the city of Seattle. We’ve scraped 100K sold listings over the past three years but found that around 20% of the listings are missing square footage data.

How do we deal with the missing data to construct our model?

We want to build a model to predict housing prices in the city of Seattle. We’ve scraped 100K sold listings over the past three years, but have discovered that around 20% of the listings are missing square footage data.

How would you approach dealing with this missing data, in order to construct the most useful predictive model possible?

We want to build a model to predict housing prices in the city of Seattle. We’ve scraped 100K sold listings over the past three years, but have discovered that around 20% of the listings are missing square footage data.

How would you approach dealing with this missing data, in order to construct the most useful predictive model possible?



Given two strings, write a function to return <code>True</code> if the strings are anagrams of each other and <code>False</code> if they are not.

Note: A word is not an anagram of itself.

Example 1:

Input:

<pre tabindex="0" class="chroma"><code>string_1 = &#34;listen&#34;
string_2 = &#34;silent&#34;
</code></pre>

Output:

<pre tabindex="0" class="chroma"><code>True
</code></pre>

Example 2:

Input:

<pre tabindex="0" class="chroma"><code>string_1 = &#34;banana&#34;
string_2 = &#34;bandana&#34;
</code></pre>

Output:

<pre tabindex="0" class="chroma"><code>False
</code></pre>

Valid Anagram

How would you explain the concept of linear regression to three different audiences: a child, a first-year college student, and a seasoned mathematician? Ensure your explanations are tailored to the understanding level of each audience.

Describe linear regression to various audiences with different levels of knowledge.

Explaining Linear Regression to Different Audiences

You are given a dictionary with two keys <code>a</code> and <code>b</code> that hold integers as their values.

Without declaring any other variable, swap the value of <code>a</code> with the value of <code>b</code> and vice versa.

Note: Return the dictionary after editing it.

Example:

Input:

<pre tabindex="0" class="chroma"><code>numbers = {
 &#39;a&#39;:3,
 &#39;b&#39;:4
}
</code></pre>

Output:

<pre tabindex="0" class="chroma"><code>def swap_values(numbers) -&gt; {&#39;a&#39;:4,&#39;b&#39;:3}
</code></pre>

Swap Variables

Write a function <code>fib</code> which takes an integer <code>n</code> and returns the nth fibonacci number. For this question, <code>fib</code> MUST be recursively defined.

Note: <code>for</code> and <code>while</code> keywords are disabled for this question, as well as <code>functools</code>. Any workarounds around this restriction is prohibited.

Example:

Input:

<pre tabindex="0" class="chroma"><code>n = 4
</code></pre>

Output:

<pre tabindex="0" class="chroma"><code>def fib(n) -&gt; 3
# the sequence is [1, 1, 2, 3, 5, 8...]
</code></pre>

Implement a dynamic recursive fibonacci function.

Impossibly Iterative Fibonacci

An ecommerce company is experiencing a reduction in revenue for the past 12 months. You have the following transaction data:

<ul>
<li>Date of sale</li>

<li>Total $ Amount paid by customer</li>

<li>Profit Margin per unit</li>

<li>Quantity of item</li>

<li>Item category</li>

<li>Item subcategory</li>

<li>Marketing attribution source</li>

<li>% discount applied</li>
</ul>

How would you analyze the dataset to understand exactly where the revenue loss is occurring?

Let’s say you’re interning at a fintech startup that’s building a platform for online games of chance. During testing, one of your simulations flips a coin 10 times and gets 8 tails and 2 heads.

How would you determine if the coin is fair, and what statistical approach would you use to support your conclusion?

How would you assess if a coin is fair after observing 8 tails in 10 flips?

Fair Coin

Probability

How comfortable are you presenting your insights?

What are the logistic and softmax functions? What is the difference between the two?

What makes them useful for use in logistic regression?

In logistic regression, how is the predicted class determined based on the logistic function?

In logistic regression, how is the predicted class determined based on the logistic function?

Softmax vs Logistic II

What is the key characteristic of the logistic function that makes it useful for mapping continuous values to a probability?

What is the key characteristic of the logistic function that makes it useful for mapping continuous values to a probability?

Softmax vs Logistic I

We’re expanding our data engineering capabilities across Mexico, Brazil, Argentina, Colombia, Chile, and Peru, and we’re hiring a Senior Clinical Data Engineer to help build the foundation of this new regional function. In this role, you’ll lead the development and optimization of clinical data systems, drive data standardization, build validation frameworks, and design high‑performance databases and pipelines across global trials. The Senior Clinical Data Engineer leads the strategic development and optimization of clinical data systems to support regulatory compliance, advanced analytics, and operational excellence across global trials. This role drives enterprise-level data standardization initiatives, and architects scalable validation frameworks to proactively address systemic data issues. With deep expertise in Python, R, SQL, and SAS, the engineer builds and maintains modular codebases, sets coding standards, and mentors junior engineers. The role also oversees regulatory alignment with GCP and FDA 21 CFR Part 11, establishing robust documentation and audit trail protocols. Through dynamic dashboards and analytics tools, the engineer delivers actionable insights into trial performance and data quality. As a strategic liaison across Biostatistics, Clinical Operations, and Regulatory Affairs, the engineer translates clinical requirements into scalable technical solutions and leads the design of secure, high-performance databases and ETL pipelines integrating data from diverse clinical systems. Essential functions of the job include but are not limited to: Data Standardization & Mapping: Spearhead the development of enterprise-level data mapping strategies that transform raw clinical data into standardized formats for high-impact analytics. Lead the adoption and governance of data standards across programs to ensure regulatory alignment and consistency. Data Quality Assurance: Design and implement robust, scalable validation frameworks that proactively detect and resolve systemic data issues. Serve as a strategic partner to Clinical Data Managers and cross-functional teams, driving continuous improvement in data integrity across global trials Programming & Scripting: Architect and maintain advanced, modular codebases using Python, R, SQL, and SAS to support complex data engineering workflows. Establish coding standards and mentor junior engineers in automation, reproducibility, and performance optimization. Example use cases includes edit checks, reconciliations, exception listings, programmed protocol deviations, resource projections based on site data entry volume Regulatory Compliance & Documentation: Lead compliance initiatives to ensure all data systems and workflows meet GCP, FDA 21 CFR Part 11, and evolving global regulatory requirements. Define documentation protocols and oversee audit trail governance to support inspection readiness and transparency. Reporting & Visualization - Develop and operationalize dynamic dashboards and analytics tools that provide real-time insights into data quality, trial progress, and operational KPIs. Translate complex datasets into actionable intelligence for clinical and regulatory stakeholders. Collaboration & Cross-Functional Support: Act as a strategic liaison between Clinical Data Engineering and Biostatistics, Clinical Operations, and Regulatory Affairs. Translate clinical and scientific requirements into scalable technical solutions that support study execution and data delivery. Database Design & Optimization: Lead the design and optimization of secure, high-performance relational databases and data lakes. Ensure infrastructure scalability, query efficiency, and data governance for large-scale clinical datasets. Qualifications Minimum Required: <ul><li>Bachelor’s Degree in a relevant field (life sciences, statistics, data management, clinical operations) or relevant/equivalent combination of education, training, and experience</li><li>Minimum 6 years experience in clinical monitoring, clinical trial management or equivalent</li><li>Advanced programming and automation skills; database design; dashboard development; CDISC governance</li><li>Professional working proficiency in English </li></ul>Other Required <ul><li>Highly effective oral and written communication skills with the ability to communicate effectively with project team members</li><li>Excellent organizational and time management skills</li><li>Ability to work in a team or independently as required</li><li>Demonstrated ability to learn how to extract pertinent information from protocols, electronic study data systems and clinical systems</li><li>Proficiency in statistical analysis and data monitoring tools.</li><li>Detail-oriented with strong analytical and problem-solving skills</li><li>Demonstrated experience with integrated risk planning & management</li><li>Ability to mentor junior team members </li></ul>Preferred <ul><li>CRO experience as a Clinical Data Engineer or Programmer </li></ul>Skills <ul><li>Strong analytical and problem-solving skills with attention to data quality and integrity.</li><li>Ability to work with large, complex datasets from multiple sources.</li><li>Effective communication skills to collaborate with cross-functional teams.</li><li>Knowledge of data governance, privacy, and security best practices in clinical research. </li></ul>Competencies <ul><li>Collaboration: Works effectively with clinical, statistical, and technical teams to align data strategies with study goals.</li><li>Accountability: Takes ownership of data engineering deliverables and ensures timely, high-quality outputs.</li><li>Adaptability: Thrives in a fast-paced, evolving environment with shifting priorities and timelines.</li><li>Compliance-Oriented: Maintains a strong focus on regulatory compliance and data traceability. </li></ul>Any data provided as a part of this application will be stored in accordance with our <a>Privacy Policy.</a> For CA applicants, please also refer to our <a>CA Privacy Notice</a>. Precision Medicine Group is an Equal Opportunity Employer. Employment decisions are made without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status or other characteristics protected by law. If you are an individual with a disability and require a reasonable accommodation to complete any part of the application process or are limited in the ability or unable to access or use this online application process and need an alternative method for applying, you may contact Precision Medicine Group at QuestionForHR@precisionmedicinegrp.com. It has come to our attention that some individuals or organizations are reaching out to job seekers and posing as potential employers presenting enticing employment offers. We want to emphasize that these offers are not associated with our company and may be fraudulent in nature. Please note that our organization will not extend a job offer without prior communication with our recruiting team, hiring managers and a formal interview process.

Calculate Moving Average	SQL	Easy
Predict Customer Churn	Machine Learning	Medium
A/B Test Significance	Statistics	Medium
Optimize Query Performance	SQL	Hard
Feature Importance Analysis	Machine Learning	Medium
Clean Missing Data	Python	Easy
Neural Network Architecture	Deep Learning	Hard
Calculate Cohort Retention	SQL	Medium
Bayesian Probability	Statistics	Easy
Recommend Similar Products	Machine Learning	Hard

Precision medicine group Interview Questions

Overview

Precision medicine group Interview Guides

Challenge

Precision medicine group Interview Questions

Precision medicine group Opening Jobs

Discussion & Interview Experiences

Discussion & Interview Experiences