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Alpha clinical systems Interview Questions

alpha clinical systems (acs) is the leading provider of affordable, flexible and comprehensive esource solutions for life sciences companies. developers of acs360, a fully-integrated, cloud-based platform that captures esource data directly—with or without existing edc systems—acs is dedicated to streamlining and modernizing clinical trials for small to mid-size sites, sponsors and cros. acs360 eliminates slow, error-prone paper-based processes to streamline and automate workflows, from study design and build to direct esource data capture and real-time data visualization. the fully-integrated acs360 platform is comprised of esource, econsent, epro/ecoa, electronic drug inventory management, recruiting, regulatory documents and budget management.

alpha clinical systems (acs) is the leading provider of affordable, flexible and comprehensive esource solutions for life sciences companies. developers of acs360, a fully-integrated, cloud-based platform that captures esource data directly—with or without existing edc systems—acs is dedicated to streamlining and modernizing clinical trials for small to mid-size sites, sponsors and cros. acs360 eliminates slow, error-prone paper-based processes to streamline and automate workflows, from study design and build to direct esource data capture and real-time data visualization. the fully-integrated acs360 platform is comprised of esource, econsent, epro/ecoa, electronic drug inventory management, recruiting, regulatory documents and budget management.

Overview

Alpha clinical systems Interview Guides

Data Structures & Algorithms

Compute Deviation

Given two sorted lists, write a function to merge them into one sorted list.

Merge Sorted Lists

Find Bigrams

Write a function to create a single dataframe with complete addresses in the format of street, city, state, zip code.

Complete Addresses

Get Top N Frequent Words

Select the 2nd highest salary in the engineering department

2nd Highest Salary

Write a SQL query to create a histogram of the number of comments per user in the month of January 2020.

Comments Histogram

Write a query that returns all neighborhoods that have 0 users.

Empty Neighborhoods

Calculate the first touch attribution for each `user_id` that converted.

First Touch Attribution

Closest SAT Scores

Machine Learning

Encoding Categorical Features

Coefficients of Logistic Regression

Booking Regression

Job Recommendation

Say you are given a dataset of perfectly linearly separable data. What would happen when you run logistic regression?

Perfectly Separable

Probability

First to Six

500 Cards

Raining in Seattle

Found Item

Ad Raters

Statistics

P-value to a Layman

Reducing Error Margin

What are the assumptions of linear regression?

Assumptions of Linear Regression

You are testing hundreds of hypotheses with many t-tests. What considerations should be made?

Hundreds of Hypotheses

What statistical test could you use to determine which of two parcel types is better to use, given how often they are damaged?

Different Parcel Effectiveness

Challenge

When an interviewer asks a question along the lines of:

<ul>
<li>What would your current manager say about you? What constructive criticisms might he give?</li>
<li>What are your three biggest strengths and weaknesses you have identified in yourself?</li>
</ul>

How would you respond?

When asked about your strengths in an interview, what is an effective way to respond?

When asked about your strengths in an interview, what is an effective way to respond?

Your Strengths and Weaknesses I

Which of the following is an acceptable strategy when discussing weaknesses in an interview?

Which of the following is an acceptable strategy when discussing weaknesses in an interview?

Your Strengths and Weaknesses II

What do you tell an interviewer when they ask you what your strengths and weaknesses are?

Your Strengths and Weaknesses

Brainteasers

When an interviewer asks you a question along the lines of:

<ul>
<li>Why did you apply to our company?</li>
<li>What are you looking for in your next job?</li>
<li>What makes you a good fit for our company?</li>
</ul>

How should you respond?

When asked 'What are you looking for in your next job?' in an interview, how can you tie the company's employee benefits into your response?

When asked 'What are you looking for in your next job?' in an interview, how can you tie the company's employee benefits into your response?

Why Do You Want to Work With Us I

How can company values be used effectively in an interview when asked 'What makes you a good fit for our company?'

How can company values be used effectively in an interview when asked 'What makes you a good fit for our company?'

Why Do You Want to Work With Us II

When responding to the question 'Why did you apply to our company?' during an interview, what aspect should you highlight?

When responding to the question 'Why did you apply to our company?' during an interview, what aspect should you highlight?

Why Do You Want to Work With Us III

How would you answer when an Interviewer asks why you applied to their company?

Why Do You Want to Work With Us

Describe a data project you worked on. What were some of the challenges you faced?

Describing a data project and its challenges

Hurdles In Data Projects

Analytics

How would you explain what a p-value is to someone who is not technical?

What does a p-value in a statistical test represent?

What does a p-value in a statistical test represent?

P-value to a Layman I

In a statistical test, how does a low p-value (less than 0.05) influence our decision about the null hypothesis?

In a statistical test, how does a low p-value (less than 0.05) influence our decision about the null hypothesis?

P-value to a Layman II

What are the assumptions of linear regression?

Which assumption of the residuals of the standard linear regression model can not be overcome by increasing the sample size?

Regression assumptions

Let’s say that you’re training a classification model.

How would you combat overfitting when building tree-based models?

Let's say that you're training a classification model.   How would you combat overfitting when building tree-based models?

Overfit Avoidance

How would you handle the data preparation for building a machine learning model using imbalanced data?

Addressing imbalanced data in machine learning through carefully prepared techniques.

Data Preparation for Imbalanced Data

Let’s say we’re comparing two machine learning algorithms. In which case would you use a bagging algorithm versus a boosting algorithm? 

Give an example of the tradeoffs between the two.

In machine learning, when would you use a bagging algorithm over a boosting algorithm?

In machine learning, when would you use a bagging algorithm over a boosting algorithm?

Bagging vs. Boosting

Bagging vs Boosting

Talk about a time when you had trouble communicating with stakeholders. How were you able to overcome it?

Strategically resolving misaligned expectations with stakeholders for a successful project outcome

Stakeholder Communication

Given a string, write a function to determine if it is palindrome or not.

Note: A palindrome is a word/string that is read the same way forward as it is backward, e.g. <code>&#39;reviver&#39;</code>, <code>&#39;madam&#39;</code>, <code>&#39;deified&#39;</code> and <code>&#39;civic&#39;</code> are all palindromes, while <code>&#39;tree&#39;</code>, <code>&#39;music&#39;</code> and <code>&#39;person&#39;</code> are not palindromes.

Example:

Input:

<pre tabindex="0" class="chroma"><code>word1 = &#34;tree&#34;
word2 = &#34;radar&#34;
</code></pre>

Output:

<pre tabindex="0" class="chroma"><code>def is_palindrome(word1) -&gt; False
def is_palindrome(word2) -&gt; True
</code></pre>

Given a string, write a function to determine if it is palindrome or not.

String Palindromes

Write a SQL query to select the 2nd highest salary in the engineering department.

Note: If more than one person shares the highest salary, the query should select the next highest salary.

Example:

Input:

<code>employees</code> table

<table>
<thead>
<tr>
<th>Column</th>
<th>Type</th>
</tr>
</thead>

<tbody>
<tr>
<td><code>id</code></td>
<td>INTEGER</td>
</tr>

<tr>
<td><code>first_name</code></td>
<td>VARCHAR</td>
</tr>

<tr>
<td><code>last_name</code></td>
<td>VARCHAR</td>
</tr>

<tr>
<td><code>salary</code></td>
<td>INTEGER</td>
</tr>

<tr>
<td><code>department_id</code></td>
<td>INTEGER</td>
</tr>
</tbody>
</table>
<code>departments</code> table

<table>
<thead>
<tr>
<th>Column</th>
<th>Type</th>
</tr>
</thead>

<tbody>
<tr>
<td><code>id</code></td>
<td>INTEGER</td>
</tr>

<tr>
<td><code>name</code></td>
<td>VARCHAR</td>
</tr>
</tbody>
</table>
Output:

<table>
<thead>
<tr>
<th>Column</th>
<th>Type</th>
</tr>
</thead>

<tbody>
<tr>
<td><code>salary</code></td>
<td>INTEGER</td>
</tr>
</tbody>
</table>

Imagine you are asked to build a machine learning model to decide new loan approvals for a
financial firm. You ask the data department in the company for a subset of data to get started
working on the problem. The data includes different features about applicants such as age,
occupation, zip code, height, number of children, favorite color, etc. You decide to build
multiple machine learning models to test out different ideas before settling on the best one.

How would you explain the bias-variance tradeoff with regards to
building and choosing a model to use?

Bias vs. Variance Tradeoff

Explain the difference between the XGBoost and random forest algorithms and give an example where you would use one over the other.

Why might a data scientist choose to use XGBoost instead of Random Forest for a particular machine learning task?

Why might a data scientist choose to use XGBoost instead of Random Forest for a particular machine learning task?

XGBoost vs Random Forest: Choice

Xgboost vs Random Forest

How does random forest generate the forest? Additionally, why would we use it over other algorithms such as logistic regression?

What happens when you average the output on multiple decision trees?

What happens when you average the output on multiple decision trees?

Average Trees

Random Forest Explanation

What is the difference between Logistic and Linear Regression?

When would use one instead of the other in practice?

What is the difference between Logistic and Linear Regression?

Linear vs Logistic Regression

Let’s say that you work at a B2B SAAS company that’s interested in testing the pricing of different levels of subscriptions.

Your project manager comes to you and asks you to run a two-week-long A/B test to test an increase in pricing.

How would you approach designing this test? How would you determine whether the increase in pricing is a good business decision?

Testing Price Increase

A/B Testing

Tell me about a project in which you had to clean and organize a large dataset.

Describing a real-world data cleaning and organization project

Data Cleaning Experiences

Data Pipelines

A team wants to A/B test multiple different changes through a sign-up funnel.

For example, on a page, a button is currently red and at the top of the page. They want to see if changing a button from red to blue and/or from the top of the page to the bottom of the page will increase click-through.

How would you set up this test?

Your team wants to run an AB test on the color (red or blue) and position (top/bottom of the page) of a button that links to a promotion.

How many different variants of the test should you run to see the effect that a red button has on the bottom of the page, if currently the button is blue and on the top of the page.

Your team wants to run an AB test on the color (red or blue) and position (top/bottom of the page) of a button that links to a promotion.

How many different variants of the test should you run to see the effect that a red button has on the bottom of the page, if currently the button is blue and on the top of the page.

A/B Test Variants

Button AB Test

Let’s say we want to launch a re-design of a landing page to improve the click-through rate. We can do this by implementing an AB test.
Given that we launch an AB test, how would you infer if the results of the click-through rate were statistically significant or not?

How can you accurately conclude if the results of an A/B test, conducted to evaluate the effectiveness of a landing page redesign, are statistically significant?

How can you accurately conclude if the results of an A/B test, conducted to evaluate the effectiveness of a landing page redesign, are statistically significant?

Statistically Significant Test

Precisely ascertain whether the outcomes of an A/B test, executed to assess the impact of a landing page redesign, exhibit statistical significance.

Given an array and a target integer, write a function <code>sum_pair_indices</code> that returns the indices of two integers in the array that add up to the target integer. If not found, just return an empty list.

Note: Can you do it on \(O(n)\) time?

Note: Even though there could be many solutions, only one needs to be returned.

Example 1:

Input:

<pre tabindex="0" class="chroma"><code>array = [1 2 3 4] 
target = 5 
</code></pre>

Output:

<pre tabindex="0" class="chroma"><code>def sum_pair_indices(array, target) -&gt; [0 3] or [1 2]
</code></pre>

Example 2:

Input:

<pre tabindex="0" class="chroma"><code>array = [3]
target = 6 
</code></pre>

Output:

<pre tabindex="0" class="chroma"><code>Do NOT return [0 0] as you can&#39;t use an index twice.
</code></pre>

Given an array and a target integer, write a function that returns the indices of two integers in the array that add up to the target integer.

Target Indices

Let’s say that your company is running a standard control and variant AB test on a feature to increase conversion rates on the landing page. The PM checks the results and finds a .04 p-value.

How would you assess the validity of the result?

Experiment Validity

Let’s say that you work at a bank that wants to build a model to detect fraud on the platform.

The bank wants to implement a text messaging service in addition that will text customers when the model detects a fraudulent transaction in order for the customer to approve or deny the transaction with a text response.

How would we build this model?

Let’s say that you work at a bank that wants to build a model to detect fraud on the platform.

The bank wants to implement a text messaging service that will text customers when the model detects a fraudulent transaction in order for the customer to approve or deny the transaction with a text response.

Which statement is true?

Let's say that you work at a bank that wants to build a model to detect fraud on the platform.

The bank wants to implement a text messaging service that will text customers when the model detects a fraudulent transaction in order for the customer to approve or deny the transaction with a text response.

Which statement is true?

Bank Fraud Model

Let’s say you work at Allstate. Allstate is running <code>N</code> online ads right now. The table <code>ads</code> contains all those ads, ranked by popularity via the <code>id</code> column (e.g., the entry with <code>id = 1</code> is the most popular, etc.).

Create a subquery or common table expression named <code>top_ads</code> containing the top 3 ads (by popularity) and return the number of rows that would result from the following operations

<ol>
<li><code>ads INNER JOIN top_ads</code></li>
<li><code>ads LEFT JOIN top_ads</code></li>
<li><code>ads RIGHT JOIN top_ads</code></li>
<li><code>ads CROSS JOIN top_ads</code></li>
</ol>

Note: Please make the <code>join_type</code> column in your output have the values <code>inner_join</code>, <code>left_join</code>, etc. for each of their respective join types

Note: Please return only one query with each number in a different row

Example:

Input:

<table>
<thead>
<tr>
<th>Column</th>
<th>Type</th>
</tr>
</thead>

<tbody>
<tr>
<td><code>id</code></td>
<td>INTEGER</td>
</tr>

<tr>
<td><code>name</code></td>
<td>VARCHAR</td>
</tr>
</tbody>
</table>
Output:

<table>
<thead>
<tr>
<th>Column</th>
<th>Type</th>
</tr>
</thead>

<tbody>
<tr>
<td><code>join_type</code></td>
<td>VARCHAR</td>
</tr>

<tr>
<td><code>number_of_rows</code></td>
<td>INTEGER</td>
</tr>
</tbody>
</table>

Size of Joins

Given an integer <code>N</code>, write a function that returns a list of all of the prime numbers up to <code>N</code>.

Note: Return an empty list there are no prime numbers less than or equal to <code>N</code>.

Example:

Input:

<pre tabindex="0" class="chroma"><code>N = 3
</code></pre>

Output:

<pre tabindex="0" class="chroma"><code>def prime_numbers(N) -&gt; [2,3]
</code></pre>

Given an integer N, write a function that returns all of the prime numbers up to N

Prime to N

Regularization and cross-validation are two common techniques used to improve the performance of machine learning algorithms.

When should you use one versus the other?

Given the choices below, which one is an example of a scenario where we should be using regularization?

Given the choices below, which one is an example of a scenario where we should be using regularization?

Regularization Example

Regularization and Validation

What’s the difference between Lasso and Ridge Regression?

Under what circumstances is it recommended to use Lasso regression over Ridge regression?

Under what circumstances is it recommended to use Lasso regression over Ridge regression?

Lasso vs Ridge

<h1>Binary Tree Validation</h1>

You are given the root of a binary tree. You need to determine if it is a valid binary search tree (BST).

A valid BST is defined as follows:

<ul>
<li>The left subtree of a node contains only nodes with values less than or equal to the node’s value.</li>
<li>The right subtree of a node contains only nodes with values greater than or equal to the node’s value.</li>
<li>Both the left and right subtrees must also be binary search trees.</li>
</ul>

Given the function <code>def is_valid_bst(root: Node) -&gt; bool:</code>, return True if the binary tree is a valid BST. Otherwise, return False.

<h3>Example:</h3>

Input:

<img src="/s3/questions/9664817c-3e12-4a40-9236-8382b13f55a0.png" alt="image"/>Converted Binary Tree.png

Output:

<pre tabindex="0" class="chroma"><code>def is_valid_bst(Node(3)) -&gt; True
</code></pre>

Given the root node, verify if a binary search tree is valid or not.

Binary Tree Validation

How would you convey insights and the methods you use to a non-technical audience?

Making data-driven insights actionable for those without technical expertise

Simple Explanations

The Fibonacci sequence is a series of numbers in which each number is the sum of the two preceding ones, usually starting with 0 and 1. It is often used in algorithm examples, and is defined by the following formula: F(n) = F(n-1) + F(n-2), with F(0) = 0 and F(1) = 1.

Your task is to implement the Fibonacci algorithm in three different methods:
1. Recursively
2. Iteratively
3. Using Memoization

Example 1:

Input:

<pre tabindex="0" class="chroma"><code>n = 5
</code></pre>

Output:

<pre tabindex="0" class="chroma"><code>fibonacci(n) -&gt; 5
</code></pre>

Example 2:

Input:

<pre tabindex="0" class="chroma"><code>n = 10
</code></pre>

Output:

<pre tabindex="0" class="chroma"><code>fibonacci(n) -&gt; 55
</code></pre>

The Fibonacci sequence starts as follows: 0, 1, 1, 2, 3, 5, 8, 13, 21, 34, 55…

This question requires the implementation of the Fibonacci sequence using three different methods: recursively, iteratively, and using memoization.

Implementing the Fibonacci Sequence in Three Different Methods

What’s the relationship between PCA and K-means clustering?

What does the variable “k” in k-means clustering refer to?

What does the variable "k" in k-means clustering refer to?

Calculate Moving Average	SQL	Easy
Predict Customer Churn	Machine Learning	Medium
A/B Test Significance	Statistics	Medium
Optimize Query Performance	SQL	Hard
Feature Importance Analysis	Machine Learning	Medium
Clean Missing Data	Python	Easy
Neural Network Architecture	Deep Learning	Hard
Calculate Cohort Retention	SQL	Medium
Bayesian Probability	Statistics	Easy
Recommend Similar Products	Machine Learning	Hard

Alpha clinical systems Interview Questions

Overview

Alpha clinical systems Interview Guides

Challenge

Alpha clinical systems Interview Questions

Alpha clinical systems Salaries by Position

Discussion & Interview Experiences

Discussion & Interview Experiences