<h3>Job Description</h3><div>Job Description<div>Company Description AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn. Job Description We are seeking a highly motivated group leader (Principal Research Scientist I) for purification to join the Manufacturing Science and Technology (MSAT) group within Operations Science & Technology -Biologics organization.  Our group is responsible for the optimization, validation, implementation, and continuous improvement for commercial manufacturing of therapeutic proteins at AbbVie Bioresearch Center in Worcester, MA.  The candidate should be a discipline expert who drives functional, financial, and quality performance by controlling, improving, and troubleshooting commercial processes as well as designing and implementing studies aimed at new or improved products.Responsibilities:<ul><li>Lead a team of scientists with expertise in purification. The candidate is expected to proficiently manage manufacturing aspects of commercial support of biologics drug substance process throughout the product life cycle: from technology transfer, process validation to commercial manufacturing, and process improvement in order to meet the financial, quality and throughput objectives.</li><li>Serves as technical expert for the manufacturing plant with respect to the biological process(es).</li><li>Responsible for developing, communicating, and implementing the vision and strategy to fulfill functional goals and key scientific objectives. This also involves collaboration with experts within function to integrate scientific objectives into activities associated with development of new/improved products or technology.</li><li>Advance scientific expertise within the function and proactively demonstrates leadership by advises and sharing of expert opinions with subordinates, peers, and senior management.</li><li>The candidate also mentors and trains functional colleagues, assesses current and emerging business challenges, enabling functional goal achievement.</li><li>Ensures quality and effectiveness of key results of major project plans within function through sound design, early risk assessments, and implementation of fallback strategies.</li><li>Sources and identifies emerging scientific trends from multiple internal and external sources and assess relevance. Integrates trends into functional short-term objectives. Advances cross-discipline technology and direction through generation of data.</li><li>Applies imagination and innovation by creating, inventing, and implementing new or better approaches, alternatives and breakthrough ideas that are valued by customers within the function.</li><li>Presents scientific concepts and results for functional scientific and non-scientific leaders as well as potential and existing partners. Maximizes impact and value of expertise.</li><li>Responsible for compliance with applicable Corporate and Divisional Policies and procedures.</li></ul>Qualifications <ul><li>Master’s Degree or equivalent education in Biological Science or equivalent education with extensive biologics process purification experience (typically 12+ years of related work); PhD in Biological Science or related field with extensive biologics process purification experience (typically 6+ years of related work experience).</li><li>Proven biologics process purification technical experience in pharmaceutical companies, with ability and prior experience in the innovation of new or improved product releases, generating original technical ideas and research or development strategies.</li><li>Demonstrate creative ‘out of the box’ thinking to solve difficult technical problems and champion new technologies to achieve project goals.</li><li>Interacts well with diverse groups within function and maintains strong working relationships with internal and external collaborators.</li><li>Demonstrated ability to influence others in areas of science through excellent communication and prolific writing.</li></ul> Additional Information Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​​<ul><li>The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.​</li><li>We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​</li><li>This job is eligible to participate in our short-term incentive programs. ​​</li><li>This job is eligible to participate in our long-term incentive programs. ​</li></ul>​Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. ​​<div></div>AbbVie is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion.  It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.</div></div>

Company Description AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas - immunology, oncology, neuroscience, and eye care - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn. Job Description We are seeking a highly motivated group leader (Principal Research Scientist I) for purification to join the Manufacturing Science and Technology (MSAT) group within Operations Science & Technology -Biologics organization. Our group is responsible for the optimization, validation, implementation, and continuous improvement for commercial manufacturing of therapeutic proteins at AbbVie Bioresearch Center in Worcester, MA. The candidate should be a discipline expert who drives functional, financial, and quality performance by controlling, improving, and troubleshooting commercial processes as well as designing and implementing studies aimed at new or improved products. <h3>Responsibilities</h3> <ul> <li> Lead a team of scientists with expertise in purification. The candidate is expected to proficiently manage manufacturing aspects of commercial support of biologics drug substance process throughout the product life cycle: from technology transfer, process validation to commercial manufacturing, and process improvement in order to meet the financial, quality and throughput objectives. </li> <li> Serves as technical expert for the manufacturing plant with respect to the biological process(es). </li> <li> Responsible for developing, communicating, and implementing the vision and strategy to fulfill functional goals and key scientific objectives. This also involves collaboration with experts within function to integrate scientific objectives into activities associated with development of new/improved products or technology. </li> <li> Advance scientific expertise within the function and proactively demonstrates leadership by advises and sharing of expert opinions with subordinates, peers, and senior management. </li> <li> The candidate also mentors and trains functional colleagues, assesses current and emerging business challenges, enabling functional goal achievement. </li> <li> Ensures quality and effectiveness of key results of major project plans within function through sound design, early risk assessments, and implementation of fallback strategies. </li> <li> Sources and identifies emerging scientific trends from multiple internal and external sources and assess relevance. Integrates trends into functional short-term objectives. Advances cross-discipline technology and direction through generation of data. </li> <li> Applies imagination and innovation by creating, inventing, and implementing new or better approaches, alternatives and breakthrough ideas that are valued by customers within the function. </li> <li> Presents scientific concepts and results for functional scientific and non-scientific leaders as well as potential and existing partners. Maximizes impact and value of expertise. </li> <li> Responsible for compliance with applicable Corporate and Divisional Policies and procedures. </li> </ul> Qualifications <ul> <li> Master's Degree or equivalent education in Biological Science or equivalent education with extensive biologics process purification experience (typically 12+ years of related work); PhD in Biological Science or related field with extensive biologics process purification experience (typically 6+ years of related work experience). </li> <li> Proven biologics process purification technical experience in pharmaceutical companies, with ability and prior experience in the innovation of new or improved product releases, generating original technical ideas and research or development strategies. </li> <li> Demonstrate creative 'out of the box' thinking to solve difficult technical problems and champion new technologies to achieve project goals. </li> <li> Interacts well with diverse groups within function and maintains strong working relationships with internal and external collaborators. </li> <li> Demonstrated ability to influence others in areas of science through excellent communication and prolific writing. </li> </ul> Additional Information Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ? ? <ul> <li> The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.? </li> <li> We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.? </li> <li> This job is eligible to participate in our short-term incentive programs. ?? </li> <li> This job is eligible to participate in our long-term incentive programs. ? </li> </ul> ? Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company's sole and absolute discretion, consistent with applicable law. ? ? AbbVie is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVie's policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status. <script id="detrack" src="https://d2e48ltfsb5exy.cloudfront.net/p/t.js?i=0,1" data-g="87eb91261a9947668a0e3ce0fedea7f91624"></script>

<h3>Job Description</h3><div>Job Description<div>Company Description AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.Job Description The AbbVie portfolio consists of several marketed products in areas including eye care, immunology, oncology, virology, and women’s health as well as a pipeline containing multiple promising new molecules being studied in hundreds of clinical trials or advancing from Discovery into Development. AbbVie is a global organization with US research sites in Boston (Cambridge and Worcester, MA), Chicago (North Chicago, IL), and the San Francisco Bay Area (South San Francisco, CA). The biologics portfolio is comprised of diverse and tailored modalities including mono- and bispecific antibodies, antibody-drug conjugates, dual variable domain antibodies, antibody fragments, and other recombinant proteins as well as cell-based therapies.The Quantitative, Translational and ADME Sciences (QTAS) group is searching for an experienced project representative to provide biologics project support across all therapeutic areas for molecules in discovery and clinical development. The position requires close collaboration with Discovery and Development project teams, clinical pharmacology, and other stakeholders, developing and executing QTAS and PK/PD strategies necessary to facilitate the advancement of our pipeline.The Project Representative will be based in one of AbbVie's R&D locations: North Chicago, IL; Worcester, MA; Cambridge, MA; San Francisco, CA.Key Responsibilities:<ul><li>Serve as a QTAS representative on project teams supporting the development of novel biologics; collaborate with project team members (e.g., clinical pharmacology, protein analytics, discovery, toxicology) and groups within QTAS to generate relevant data guiding target validation, biomarker selection, and candidate selection</li> <li>Develop and drive the QTAS and PK/PD strategy for large molecule discovery, preclinical, and clinical development projects  to support decisions and milestone transitions</li> <li>Effectively communicate QTAS and PK/PD strategy and knowledge to project teams, functional leaders, and other key stakeholders to ensure alignment and influence decisions.</li> <li>Demonstrate thorough understanding of the PK/PD and  bioanalytical aspects necessary for the selection and characterization of antibodies, including considerations for bispecific antibodies, antibody-drug conjugates, and novel modalities</li> <li>Coordinate and request PK, PK/PD, and bioanalytical studies in a timely manner and communicate protocols, timelines, needs and results back to team, ensuring optimized cycle times</li> <li>Conduct value-added PK/PD-related quantitative analyses to support project team or project strategy decision-making</li> <li>Serve as a liaison with bioanalytical groups to ensure timely reagent generation, method development and sample analysis</li> <li>Prepare QTAS sections of regulatory documents (IB, IND, BLA); provide responses to regulatory questions and ensure generation of appropriate reports</li></ul>Qualifications <ul><li>Bachelor with extensive experience (14+ years), Masters with substantial experience (12+ years), or Doctorate (Ph.D.) with at least 6 years of experience in the pharmaceutical or biotechnology industries</li> <li>Experience independently representing QTAS on biologics project teams is required (expertise with novel modalities is preferred)</li> <li>Expertise with PK analysis of biologics and relevant data analysis software such as Phoenix/WinNonlin is required</li> <li>Familiarity with modeling software such as MATLAB/SimBiology, R, Python, or Berkeley Madonna is desired</li> <li>Understanding of biologics PK/PD modeling and analytical assays for measuring biologic molecules and biomarkers (including ligand binding and mass spectrometry assays) in preclinical study samples is desired</li> <li>Demonstrated scientific leadership including generating original scientific investigative strategies and guiding those efforts to an effective and productive outcome</li> <li>Recognized expert in his/her discipline</li> <li>Demonstrated publication or patent record; lead/senior author contributions a plus</li> <li>Ability to influence, negotiate and communicate effectively with both internal and external stakeholders; ability to work well in a collaborative fast-paced team environment</li> <li>Highly motivated, self-driven and results-oriented with excellent communication and presentation skills; capable of working both as team player and project driver</li> <li>High degree of flexibility in adapting to different projects and people; excellent networking and relationship-building (both internal and external) skills</li> <li>Passion for data analysis, solving technical problems and applying new technologies to further scientific goals</li> <li> </li></ul>Key Leadership Responsibilities<ul><li>Builds strong relationships with peers and cross-functionally with partners outside of team to enable higher performance</li> <li>Learns fast and can change course quickly where indicated</li> <li>Raises the bar and is never satisfied with the status quo</li> <li>Creates a learning environment, open to suggestions and experimentation for improvement</li> <li>Embraces the ideas of others, nurtures innovation and manages innovation to reality</li></ul>#LI-OnsiteApplicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: <ul><li>The compensation range described below is the range of possible base pay compensation that the Company believes in  good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual  compensation paid within this range will depend on many factors including geographic location, and we may ultimately  pay more or less than the posted range. This range may be modified in the future.</li><li>We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision  insurance and 401(k) to eligible employees.</li><li>This job is eligible to participate in our short-term incentive programs. </li><li>This job is eligible to participate in our long-term incentive programs. </li></ul> Additional Information AbbVie is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion.  It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.<div></div>AbbVie is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion.  It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.</div></div>

Overview: GENERAL SUMMARY OF POSITION: Under the general direction of the Principle Investigator, the Senior Research Scientist performs a variety of complex research experiments laboratory research on topics pertinent to the interests of the research programs of the laboratory. Responsibilities: MAJOR RESPONSIBILITIES:<ul><li>Design and implement experiments designed to further ongoing research projects, in consultation with the principal investigator.</li><li>Organize and analyze data acquired in the course of research projects.</li><li>Write manuscripts and grant applications</li><li>Design and implement research projects in the laboratory </li><li>Responsible for data acquisition, data analysis, and presentation of research results. </li><li>Train and supervise junior lab personnel, ensuring staff is trained in current methodology and safety procedures in the laboratory.</li><li>Prepare and present data for publication in public forums.</li><li>Assist in the preparation of grant applications and other research proposals.</li><li>Provide assistance in the general operation of the laboratory.</li><li>Participate regularly in laboratory meetings.</li><li>Stay current with the literature and regularly leads discussions of new reports pertinent to ongoing and proposed projects</li><li>Perform other duties as required.</li></ul> Qualifications: REQUIRED QUALIFICATIONS:<ul><li>Bachelors degree in a Biological Science, or equivalent degree</li><li>7 years of research experience.</li><li>Familiarity with general laboratory procedures.</li><li>Expertise in specific procedures and instrumentation necessary to complete specific research programs.</li><li>Current knowledge of pertinent literature.</li><li>Oral and written communication and presentation skills</li><li>Ability to travel to off-site locations</li></ul>SUPERVISION RECEIVED:Under the general direction of the Principle Investigator SUPERVISION EXERCISED:Supervises and trains new laboratory personnel and junior members of the laboratory ENVIRONMENTAL WORKING CONDITIONS:Wet chemistry laboratory, and may require appropriate contact with biohazards, radionuclides, toxins, animals, and human specimens. Additional Information: The Landers Lab at the University of Massachusetts Chan Medical School (https://www.umassmed.edu/landerslab/) has a Research Scientist, Sr. open in gene modulation therapy for ALS, Parkinsons disease and other related neurodegenerative diseases. These include gene suppression (e.g. antisense oligonucleotides activating RNAse H), gene augmentation (small activating RNAs), and gene editing (e.g. gene editing, base editing, splice modification). Our explicit goal is to develop novel technologies to advance therapeutics for numerous human diseases rapidly from pre-clinical studies to pilot studies. Candidates should be creative, highly organized, hard-working, and motivated to respond to changes within the rapidly evolving field of gene therapy. Applicants must also work independently and coordinate multiple projects, concurrently. Strong writing, verbal, and interpersonal skills are required. We offer excellent training opportunities and a competitive salary depending on experience and track record. If you have any of the above attributes and skill sets, and believe you are a good fit for our research program.Preferred qualifications:<ul><li style="margin-bottom: 3.75pt; margin-left: 21.0pt;">Masters or PhD in Neuroscience, Biochemistry and Molecular Biology, or Related Discipline.</li><li style="margin-bottom: 3.75pt; margin-left: 21.0pt;">Skilled in conventional molecular methods such as quantitative methods for qualitative and quantitative analysis of gene expression (qPCR, ddPCR, and Western blotting), gene cloning;</li><li style="margin-bottom: 3.75pt; margin-left: 21.0pt;">Experience culturing neurogenic cell lines;</li><li style="margin-bottom: 3.75pt; margin-left: 21.0pt;">Some experience in culturing and differentiation of human iPSC to neurons is preferred;</li><li style="margin-bottom: 3.75pt; margin-left: 21.0pt;">Experience with cell culture and molecular biology techniques</li><li style="margin-bottom: 3.75pt; margin-left: 21.0pt;">Experience with growing and differentiating iPSC to neurons is preferred</li><li style="margin-bottom: 3.75pt; margin-left: 21.0pt;">Experience with developing therapeutic oligonucleic acids; understanding aspects of oligonucleic acid synthesis and purification;</li><li style="margin-bottom: 3.75pt; margin-left: 21.0pt;">Experience with transcriptomic approaches including bulk RNA-Seq, scRNA-Seq, RNA isolation and quantitation and bioinformatic analysis of data;</li><li style="margin-bottom: 3.75pt; margin-left: 21.0pt;">Ability to compile and analyze data using standard statistical methods.</li></ul>Interested applicants should submit the following materials via email to Susan Jacobs (<a href="mailto:susan.jacobs@umassmed.edu" target="_blank" rel="noopener">susan.jacobs@umassmed.edu</a>) and John Landers (<a href="mailto:john.landers@umassmed.edu" target="_blank" rel="noopener">john.landers@umassmed.edu</a>): a cover letter describing current research activities and your interest in this position, a current CV (including publications), and contact information for three references.

Research Scientist Jobs in Worcester, MA

Principal Research Scientist I Msat
April 29, 2024

Principal Research Scientist I Msat
April 18, 2024

Principal Research Scientist I Dmpk Senior Biologics Project Representative Onsite
April 17, 2024

Research Scientist Sr
April 12, 2024

Research Scientist Sr
April 8, 2024

Principal Research Scientist I Msat
April 5, 2024

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Research Scientist Jobs in Worcester, MA

Principal Research Scientist I MsatApril 29, 2024

Principal Research Scientist I MsatApril 18, 2024

Principal Research Scientist I Dmpk Senior Biologics Project Representative OnsiteApril 17, 2024

Research Scientist SrApril 12, 2024

Research Scientist SrApril 8, 2024

Principal Research Scientist I MsatApril 5, 2024