Job DescriptionGeneral Summary:The Senior Principal Research Scientist is self-reliant with a proven record of accomplishments, both leading others, and independently identifying and solving complex problems using sophisticated scientific methods and analytical thought, across a number of critical and diverse projects. As a member of the Preclinical Safety Assessment (PSA) organization, this person will be responsible for the development of non-clinical safety, scientific and regulatory strategies, provide guidance, mentorship of PSA and VCGT staff, and preparation of high-quality reports and presentations.Key Duties and Responsibilities:* Designs and performs sophisticated and complex, technically challenging experiments that impact the achievement of department and project goals* PSA representative on Project and Development teams from compound selection through loss of exclusivity* Responsible for development and alignment of nonclinical strategies to support clinical development of assigned projects* Responsible for the planning, design, oversight, and communication of results from toxicology studies* Responsible for lead authorship of internal and external regulatory documents/dossiers (IB, CTX, IND, NDA, briefing books, regulatory queries, expert report etc.)* Address and resolve toxicologic issues in drug development programs, and assess the relevance of any toxicologic findings to human safety* Conduct risk assessments for impurities, degradation products, novel excipients, and metabolites* Communicate critical and significant project information to various bodies including PSA leadership, project teams and other Vertex leadership forums* Build strong scientific collaborations with external groups within the academic & industrial sectors with the intent of enhancing Vertex's PSA capabilitiesKnowledge and Skills:* Subject matter expertise in toxicology and the design and interpretation of in vitro and in vivo studies in common preclinical species* Proficient knowledge of general toxicology, the design and interpretation of studies to support regulatory submissions* Experience in the development of biologics and small molecules* Excellent written, verbal communications and ability to persuade others presenting technical/scientific concepts to diverse audiences* Strong problem solver who is highly organized with the ability to thrive and to lead in an environment with rapidly changing prioritiesEducation and Experience:* Bachelor's, Master's, or PhD in Toxicology, Pharmacology or a related life sciences* PhD and 6-8+ years, or Master's and 9+ years, or Bachelor's and 11+ year, or the equivalent combination of education and experienceFlex Designation:On-Site DesignatedFlex Eligibility Status:In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.Company InformationVertex is a global biotechnology company that invests in scientific innovation.Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Job Description
General Summary:
The Senior Principal Research Scientist is self-reliant with a proven record of accomplishments, both leading others, and independently identifying and solving complex problems using sophisticated scientific methods and analytical thought, across a number of critical and diverse projects. As a member of the Preclinical Safety Assessment (PSA) organization, this person will be responsible for the development of non-clinical safety, scientific and regulatory strategies, provide guidance, mentorship of PSA and VCGT staff, and preparation of high-quality reports and presentations.
Key Duties and Responsibilities:
Designs and performs sophisticated and complex, technically challenging experiments that impact the achievement of department and project goals
PSA representative on Project and Development teams from compound selection through loss of exclusivity
Responsible for development and alignment of nonclinical strategies to support clinical development of assigned projects
Responsible for the planning, design, oversight, and communication of results from toxicology studies
Responsible for lead authorship of internal and external regulatory documents/dossiers (IB, CTX, IND, NDA, briefing books, regulatory queries, expert report etc.)
Address and resolve toxicologic issues in drug development programs, and assess the relevance of any toxicologic findings to human safety
Conduct risk assessments for impurities, degradation products, novel excipients, and metabolites
Communicate critical and significant project information to various bodies including PSA leadership, project teams and other Vertex leadership forums
Build strong scientific collaborations with external groups within the academic & industrial sectors with the intent of enhancing Vertex’s PSA capabilities
Knowledge and Skills:
Subject matter expertise in toxicology and the design and interpretation of in vitro and in vivo studies in common preclinical species
Proficient knowledge of general toxicology, the design and interpretation of studies to support regulatory submissions
Experience in the development of biologics and small molecules
Excellent written, verbal communications and ability to persuade others presenting technical/scientific concepts to diverse audiences
Strong problem solver who is highly organized with the ability to thrive and to lead in an environment with rapidly changing priorities
Education and Experience:
Bachelor's, Master's, or PhD in Toxicology, Pharmacology or a related life sciences
PhD and 6-8+ years, or Master's and 9+ years, or Bachelor's and 11+ years, or the equivalent combination of education and experience
Flex Designation:
On-Site Designated
Flex Eligibility Status:
In this  On-Site  designated role, you will work  five days per week on-site  with ad hoc flexibility.
Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.
Company Information
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

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Job Description
General Summary:
Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has approved medicines that treat the underlying causes of multiple chronic, life-shortening genetic diseases — cystic fibrosis, sickle cell disease, and transfusion-dependent beta thalassemia — and continues to advance clinical and research programs in these diseases. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases.
The Principal Scientist will contribute to our research efforts in structural biology, biophysics, and biochemistry as an integral member of the Protein Sciences Department. The Department is responsible for all gene to structure work as well as cell-based approaches to study the mechanism of action of new and existing therapies. This role will be on-site in our state-of-the-art research facility in San Diego.
Key Duties and Responsibilities:
Provide hands-on contributions to strengthen Vertex’ internal capabilities in Cryo Electron Microscopy (CryoEM), Cryo Electron Tomography (CryoET), mechanism of action (MoA) studies, and structure-based new drug design.
Visualize macromolecular structures at a nanoscale resolution within their natural environment.
Implement AI-based technologies to facilitate protein construct design and protein structure determination.
Design and perform sophisticated and technically challenging mechanism of action studies that impact critical project goals.
Generate effective hypotheses to pursue project goals and encourage the use of new experimental approaches.
Integrate and collaborate with different functions across the organization.
Knowledge and Skills:
Deep understanding (industry experience preferred) in applying and developing emerging CryoEM, CryoET, and biophysical technologies to solve protein structures at atomic resolution and macromolecular assemblies within their natural environment.
Ability to apply AI-based techniques to facilitate protein construct design and protein structure prediction.
Experience in designing and building mechanistic assays to define mechanism of action of various therapeutic approaches.
Experience with multiparameter optimization of sample preparation.
Established reputation with a track record in the field of membrane protein biochemistry, biophysics, and structural biology.
Demonstrated independent thought/creativity in science with attention to details.
Experience in working with multi-disciplinary teams.
Excellent communication (oral and written) in articulating goals, objectives, hypotheses, and results to the group and larger cross-functional project teams.
Ability to navigate and be successful in a fast-paced, cross-functional, and multi-disciplinary work environment.
Education and Experience:
Ph.D. (or equivalent degree) in cellular biology, biochemistry, biophysics, or related disciplines and 4-7 years of relevant post-doctoral employment experience, or
Masters Degree (or equivalent degree) in cellular biology, biochemistry, biophysics, or related disciplines and 7+ years of relevant employment experience, or
Bachelors Degree (or equivalent degree) in cellular biology, biochemistry, biophysics, or related disciplines and 10+ years of relevant employment experience.
Pay Range:
$132,000 - $198,000
Disclosure Statement:
The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.
Flex Designation:
On-Site Designated
Flex Eligibility Status:
In this  On-Site  designated role, you will work  five days per week on-site  with ad hoc flexibility.
Company Information
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

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Job Description
The Medicinal Chemistry Scale-Up Research Scientist will work as part of the medicinal chemistry scaleup group with a high degree of independence to synthesize compounds on a range of scales from multi grams to hundreds of grams for biological evaluation. Performs experimental troubleshooting and methods development and ability to execute complex experimental procedures. Completes work in a resourceful, self-sufficient manner and is able to design alternative approaches to achieve desired outcomes. Keeps up to date with current scientific literature relevant to his/her scientific methodology or field(s) of technical expertise. This is an onsite position at our San Diego research site.
Key Duties and Responsibilities:
Design and undertake experimental synthetic work as part of the scale-up group to deliver material for internal customers working on 10s grams to 100s grams scale.
Personally deliver material and independently develop and optimize processes.
Work within the Scale-up group to enable rapid delivery of material, problem solve and share knowledge.
Collates and interprets complex data systematically, and synthesizes results into a cohesive body of conclusions or recommendations to guide Project decisions and new research activities.
Exercises solid judgment to prioritize studies, considering feasibility and Project impact.
Performs advanced and/or complex experimental troubleshooting.
Scours relevant scientific literature and routinely incorporates new insights into research activities.
Identifies, prioritizes and introduces relevant emerging technologies in his/her field of expertise to advance the existing technology platforms and create/maintain a competitive advantage.
Explores the feasibility of applying new scientific principles/concepts or implements and validates novel experimental approaches and technologies to achieve project goals.
Contributes significantly to patent and/or publication preparation.
Independently prepares study presentations and presents experimental conclusions.
Required Experience / Required Knowledge/Skills
Experience of working in a large-scale, synthetic laboratory to deliver complex organic compounds.
Display a flexible approach and be comfortable working on a variety of scales.
Experience of using large-scale glassware 5L to 20L.
Strong interpersonal skills and a team player.
Some experience and understanding of process safety and hazard assessment. A diligent approach to all safety matters.
Very strong synthetic knowledge and mechanistic understanding.
Required Education Level
BS and 6+ years of experience.
MS and 3 years of experience, or.
PhD or post-doc with 0 - 3 years of experience in a relevant area of research, or the equivalent industrial experience.
Pay Range:  $99,680 - $149,520
Disclosure Statement:
The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.
Company Information
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

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Job Description
We are seeking a highly motivated computational biologist with a strong background in computational methods development to join Vertex. This position is part of a rapidly growing Data and Computational Sciences team focused on developing therapies for diseases with serious unmet need. You will play a critical key role in developing cutting-edge computational methods that assess the safety and efficacy of transformative therapeutics. You will also cross-functionally collaborate to develop robust and scalable workflows that address strategic questions across Vertex’s programs. A strong background in computational methods development, a proven track record in Python programming and an ability to seamlessly collaborate will be required for success in this role.
This is a Boston based, hybrid position requiring 3 days/week onsite.

Key responsibilities:
Develop novel computational methods that address key questions regarding the efficacy, safety and integrity of cell therapies via NGS data analysis.
Leverage and extend best practices from genomics, data science and software-engineering to create industry-leading analysis software.
Collaborate with project teams and DCS members to identify key needs and questions that can be addressed using genomics.
Lead rigorous computational analyses of NGS and other biological data while developing new approaches.
Education and Experience:
Ph.D. (or equivalent degree) in computational biology, bioinformatics, human genetics, genomics, systems biology, bioengineering, or a related field and 2-5 years of productive, relevant post-doctoral employment experience, or
MS (or equivalent degree) in similar fields and 5+ years of productive, relevant employment experience, or
BS (or equivalent degree) in similar fields and 8+ years of productive, relevant employment experience.
A proven track record of next-generation sequencing (NGS) methods development pertaining to variant calling, RNA-Seq, or related data types.
Strong programming skills in Python and one or more of the following languages: Rust, Java or C/C++, and proficiency with workflow languages such as Nextflow.
Strong organizational and time-management skills.
An independent, detail-oriented, and self-motivated approach to problem solving.
A team-oriented mindset that welcomes feedback and supports others.
Excellent communication skills that can be tailored to scientists with or without computational biology expertise.
Hands-on experience customizing single cell sequencing analyses is desired.
Deep knowledge of best practices in somatic variant calling and variant annotation is ideal.

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Research Scientist Vertex Pharmaceuticals Jobs

Toxicology Senior Principal Research ScientistDecember 28, 2024

Toxicology Senior Principal Research ScientistDecember 24, 2024

Structural Biology Biophysics Principal Research ScientistDecember 24, 2024

Medicinal Chemistry Scale Up Research ScientistDecember 24, 2024

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