At Charles River, we are passionate about improving the quality of people's lives. When you join our global family, you will help create healthier lives for millions of patients and their families. Charles River employees are innovative thinkers, who are dedicated to continuous learning and improvement. We will empower you with the resources you need to grow and develop in your career. As a Charles River employee, you will be part of an industry-leading, customer-focused company at the forefront of drug development. Your skills will play a key role in bringing life-saving therapies to market faster through simpler, quicker, and more digitalized processes. Whether you are in lab operations, finance, IT, sales, or another area, when you work at Charles River, you will be the difference every day for patients across the globe. Job Summary Serve as a method development scientist in the conduct of assigned nonclinical research studies of basic to moderate complexity. ESSENTIAL DUTIES AND RESPONSIBILITIES: •Independently develop new and/or refine bioanalytical methods, followed by successful validation and transfer into Operations. •Partner with other MD Scientists, Principal Investigators, Operations Chemists, and Management to ensure method scope and performance meet the client's requirements. •Assist in assay troubleshooting, with a sense of urgency. •Contribute to the development of novel assays that evolve CRL's current analyte and/or platform offerings. •Consideration of operational efficiency and cost when developing methods. •Provide technical and scientific guidance to the research staff. •Contribute to presentations/posters/manuscripts and attend scientific meetings, conferences and training courses to enhance job and professional skills. •Perform all other related duties as assigned. Job Qualifications •Education: Bachelor's degree (B.S./B.A.) or equivalent in a scientific related discipline. Related Master's degree (M.S./M.A.) or Ph.D. highly preferred. •Experience: Minimum of 6 to 7 years related experience with a Bachelor's degree, 3 to 4 years with a Master's degree, 0 to 2 years with a Ph.D.; in the contract research, academic, or pharmaceutical industries. •An equivalent combination of education and experience may be accepted as a satisfactory substitute for the specific education and experience listed above. •Certification/Licensure: None. •Other:Hands-on experience with bioanalytical sample extraction techniques and the use of LC-MS/MS instrumentation is required. Understanding of regulatory requirements of study types assigned, as well as Testing Facility SOPs and the Good Laboratory Practices (GLPs), as appropriate. Effective written and verbal communication skills. Ability to handle multiple projects, prioritize work and meet deadlines. Proficiency in the use of standard software including Microsoft® Excel, Word, Powerpoint, etc. and with standard laboratory calculations. Compensation Data The pay range for this position is $85,000 - $95,000 USD. Please note that salaries vary within the range based on factors including, but not limited to, experience, skills, education, certifications, and location. About Safety Assessment Charles River is committed to helping our partners expedite their preclinical drug development with exceptional safety assessment services, state-of-the-art facilities and expert regulatory guidance. From individual specialty toxicology and IND enabling studies to tailored packages and total laboratory support, our deeply experienced team can design and execute programs that anticipate challenges and avoid roadblocks for a smooth, efficient journey to market.Each year approximately 120 investigational new drug (IND) programs are conducted in our Safety Assessment facilities. About Charles River Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients' clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market. With over 20,000 employees within 110 facilities in over 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client's unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. At Charles River, we are passionate about our role in improving the quality of people's lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly worked on 80% of the drugs approved by the U.S. Food and Drug Administration (FDA) in the past five years. We're committed to providing benefits that elevate your quality of life.Based on your position these may include:bonus/incentives based on performance, 401K, paid time off, stock purchase program, Health and wellness coverage, employee and family wellbeing support programs, and work life balance flexibility. Equal Employment Opportunity Charles River Laboratories is an Equal Opportunity Employer - all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status. If you are interested in applying to Charles River Laboratories and need special assistance or an accommodation due to a disability to complete any forms or to otherwise participate in the resume submission process, please contact a member of our Human Resources team by sending an e-mail message to [email protected]. This contact is for accommodation requests for individuals with disabilities only and cannot be used to inquire about the status of applications. For more information, please visit www.criver.com. 224784

For 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we'll help you build a career that you can feel passionate about.Job SummaryWe are seeking an experienced Research Scientist (Bioanalytical) for our Safety Assessment site located in Reno, NV.Serve as a scientist in the conduct of assigned preclinical and clinical research studies of basic to moderate complexity, to include study management, interpretation and reporting of study data, and assuring the regulatory compliance of these projects.We are seeking a Research Scientist I (Bioanalytical) for our Safety Assessment site located in Reno, NV.This position will serve as a scientist in the conduct of assigned nonclinical and clinical bioanalytical studies at all levels of complexity, to include study management, interpretation and reporting of study data, and assuring the regulatory compliance of these projects, as appropriate. Additional responsibilities include serving as a primary scientific contact for key clients and the on-site support of their programs, as well as the support of specialty studies. The ideal candidate will have experience with design and optimization of ligand binding assays including ELISA, MSD, or Gyrolab platforms.* Bachelor's degree (B.S./B.A.) or equivalent in a scientific related discipline. Related Master's degree (M.S./M.A.) or PhD preferred.* Minimum of 3 to 5 years related experience in the contract research, academic, or pharmaceutical industry.* An equivalent combination of education and experience may be accepted as a satisfactory substitute for the specific education and experience listed above.* Understanding of regulatory requirements of study types assigned, as well as Testing Facility SOPs and the Good Laboratory Practices (GLPs), as appropriate.* Effective written and verbal communication skills.* Ability to handle multiple projects, prioritize work and meet deadlines.* Proficiency in the use of standard software including Microsoft Excel, Word, Powerpoint, etc. and with standard laboratory calculations.The pay range for this position is $90,000 to $105,000 annually USD. Please note that salaries vary within the range based on factors including, but not limited to, experience, skills, education, certifications, and locationAbout Safety AssessmentCharles River is committed to helping our partners expedite their preclinical drug development with exceptional safety assessment services, state-of-the-art facilities and expert regulatory guidance. From individual specialty toxicology and IND enabling studies to tailored packages and total laboratory support, our deeply experienced team can design and execute programs that anticipate challenges and avoid roadblocks for a smooth, efficient journey to market. Each year approximately 300 investigational new drug (IND) programs are conducted in our Safety Assessment facilities.About Charles RiverCharles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients' clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.With over 17,000 employees within 90 facilities in 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client's unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. And in 2019, revenue increased to $2.62 billion.At Charles River, we are passionate about our role in improving the quality of people's lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of ~85% of the drugs approved by the FDA in 2019.Equal Employment OpportunityCharles River Laboratories is an Equal Opportunity Employer - M/F/Disabled/Vet.If you are interested in applying to Charles River Laboratories and need special assistance or an accommodation due to a disability to complete any forms or to otherwise participate in the resume submission process, please contact a member of our Human Resources team by sending an e-mail message to crrecruitment_US@crl.com. This contact is for accommodation requests for individuals with disabilities only and cannot be used to inquire about the status of applications.For more information, please visit www.criver.com.225077

Bioanalytical Chemistry supports the evaluations of test compounds by providing bioanalytical quantitative analysis of drug in body fluids and tissues from non-regulated and regulated studies including preclinical safety evaluations, pharmacokinetic/ Research Scientist, Analytical Chemist, Chemistry, Development, Analytical, Research, Technology, Healthcare

At Charles River, we are passionate about improving the quality of people's lives. When you join our global family, you will help create healthier lives for millions of patients and their families. Charles River employees are innovative thinkers, who are dedicated to continuous learning and improvement. We will empower you with the resources you need to grow and develop in your career. As a Charles River employee, you will be part of an industry-leading, customer-focused company at the forefront of drug development. Your skills will play a key role in bringing life-saving therapies to market faster through simpler, quicker, and more digitalized processes. Whether you are in lab operations, finance, IT, sales, or another area, when you work at Charles River, you will be the difference every day for patients across the globe. Job Summary Serve as a method development scientist in the conduct of assigned nonclinical research studies of basic to moderate complexity. ESSENTIAL DUTIES AND RESPONSIBILITIES: •Independently develop new and/or refine bioanalytical methods, followed by successful validation and transfer into Operations. •Partner with other MD Scientists, Principal Investigators, Operations Chemists, and Management to ensure method scope and performance meet the client's requirements. •Assist in assay troubleshooting, with a sense of urgency. •Contribute to the development of novel assays that evolve CRL's current analyte and/or platform offerings. •Consideration of operational efficiency and cost when developing methods. •Provide technical and scientific guidance to the research staff. •Contribute to presentations/posters/manuscripts and attend scientific meetings, conferences and training courses to enhance job and professional skills. •Perform all other related duties as assigned. Job Qualifications •Education: Bachelor's degree (B.S./B.A.) or equivalent in a scientific related discipline. Related Master's degree (M.S./M.A.) or Ph.D. highly preferred. •Experience:Minimum of 6 to 7 years related experience with a Bachelor's degree, 3 to 4 years with a Master's degree, 0 to 2 years with a Ph.D.; in the contract research, academic, or pharmaceutical industries. •An equivalent combination of education and experience may be accepted as a satisfactory substitute for the specific education and experience listed above. •Certification/Licensure: None. •Other: Hands-on experience with bioanalytical sample extraction techniques and the use of LC-MS/MS instrumentation is required. Understanding of regulatory requirements of study types assigned, as well as Testing Facility SOPs and the Good Laboratory Practices (GLPs), as appropriate. Effective written and verbal communication skills. Ability to handle multiple projects, prioritize work and meet deadlines. Proficiency in the use of standard software including Microsoft® Excel, Word, Powerpoint, etc. and with standard laboratory calculations. Compensation Data The pay range for this position is $85,000 - $95,000 USD. Please note that salaries vary within the range based on factors including, but not limited to, experience, skills, education, certifications, and location. About Safety Assessment Charles River is committed to helping our partners expedite their preclinical drug development with exceptional safety assessment services, state-of-the-art facilities and expert regulatory guidance. From individual specialty toxicology and IND enabling studies to tailored packages and total laboratory support, our deeply experienced team can design and execute programs that anticipate challenges and avoid roadblocks for a smooth, efficient journey to market.Each year approximately 120 investigational new drug (IND) programs are conducted in our Safety Assessment facilities. About Charles River Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients' clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market. With over 20,000 employees within 110 facilities in over 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client's unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. At Charles River, we are passionate about our role in improving the quality of people's lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly worked on 80% of the drugs approved by the U.S. Food and Drug Administration (FDA) in the past five years. We're committed to providing benefits that elevate your quality of life.Based on your position these may include:bonus/incentives based on performance, 401K, paid time off, stock purchase program, Health and wellness coverage, employee and family wellbeing support programs, and work life balance flexibility. Equal Employment Opportunity Charles River Laboratories is an Equal Opportunity Employer - all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status. If you are interested in applying to Charles River Laboratories and need special assistance or an accommodation due to a disability to complete any forms or to otherwise participate in the resume submission process, please contact a member of our Human Resources team by sending an e-mail message to [email protected]. This contact is for accommodation requests for individuals with disabilities only and cannot be used to inquire about the status of applications. For more information, please visit www.criver.com. 224782

For 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we'll help you build a career that you can feel passionate about. Job Summary Bioanalytical Chemistry supports the evaluations of test compounds by providing bioanalytical quantitative analysis of drug in body fluids and tissues from non-regulated and regulated studies including preclinical safety evaluations, pharmacokinetic/pharmacodynamic studies, and clinical trials.Staff participate in the development and validation of quantitative LC/MS/MS methodology, sample analysis, and interpretation and reporting of data utilizing validated hardware and software systems.This includes the development of sample extraction techniques, rapid LC separations, and employment of laboratory robotics to enhance delivery time of bioanalytical data.Staff are also knowledgeable in the application of GxP's and applicable SOPs, along with adhering to study protocols to accurately document methods, procedures, and results for inclusion into study reports and regulatory documents. Essential Functions (The fundamental Competencies/Skills & Responsibilities of the role (products and services provided/results accomplished) include, but are not limited to, those listed: <ul> <li>Efficiently perform and document all procedures, materials and results in compliance with applicable regulatory standards as applicable (protocols, methods, SOPs, etc.)</li> <li>Actively communicate and collaborate across operational areas in order to adhere to timelines and produce quality data</li> <li>Assist with the completion of laboratory investigations, assay troubleshooting, quality observations, and problem solving of technical and/or regulatory issues with minimal oversight</li> <li>Effectively develop and validate quantitative/qualitative methods/procedures with increased complexity/scope in one operational area with minimal oversight</li> <li>Independently perform data analysis in appropriate software for a majority of analytical platforms within an operational area</li> <li>Independently operate laboratory instruments including their respective software applications for 1-2 analytical platforms within an operational platform</li> <li>Develop critical thinking, troubleshooting and time management skills aligned with needs of operational areas</li> <li>Demonstrate effective communication skills through informal discussions with peers, supervisor, and team</li> <li>Able to recognize method and/or data issues and communicate them to management to minimize study impact independently</li> <li>Independently prepare summary of method development data</li> <li>Write both study and non-study deviations with minimal oversight</li> <li>Full understanding of regulatory and GXP requirements, industry standards and company SOPs within one operational area</li> <li>Independently lead the lab staff in the completion of method validation studies</li> <li>Provide support to staff members as required by operational area as needed</li> <li>Actively participate in internal process improvements, presentations and harmonization efforts</li> <li>Performs all other related duties as assigned</li> </ul> The pay range for this role is $80-85K. Please note that salaries vary within the range based on factors including, but not limited to, experience, skills, education, certifications, and location Job Qualifications (Knowledge, Experience, Skills and Abilities required to accomplish the essential functions) include but are not limited to: <ul> <li>Bachelor's degree (BA/BS) with 7-9 years of relevant working experience.Master's degree (MS) with 3-4 years of relevant working experience.Doctorate degree (PhD) with 1-2 years of relevant working experience</li> <li>An equivalent combination of education and experience may be accepted as a satisfactory substitute for the specific education and experience listed above</li> <li>Ability to communicate verbally and in writing at all levels inside and outside the organization</li> <li>Basic familiarity with Microsoft Office Suite</li> <li>Computer skills, commensurate with Essential Functions, including the ability to learn a validated system</li> <li>Ability to work extended hours beyond normal work schedule to include, but not limited to evenings, weekends, extended shifts, and/or extra shifts; sometimes on short notice</li> <li>Ability to work under specific time constraints</li> </ul> About Safety Assessment Charles River is committed to helping our partners expedite their preclinical drug development with exceptional safety assessment services, state-of-the-art facilities and expert regulatory guidance. From individual specialty toxicology and IND enabling studies to tailored packages and total laboratory support, our deeply experienced team can design and execute programs that anticipate challenges and avoid roadblocks for a smooth, efficient journey to market.Each year approximately 300 investigational new drug (IND) programs are conducted in our Safety Assessment facilities. About Charles River Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients' clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market. With over 20,000 employees within 110 facilities in over 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client's unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. At Charles River, we are passionate about our role in improving the quality of people's lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly worked on 80% of the drugs approved by the U.S. Food and Drug Administration (FDA) in the past five years. We're committed to providing benefits that elevate your quality of life.Based on your position these may include:bonus/incentives based on performance, 401K, paid time off, stock purchase program, Health and wellness coverage, employee and family wellbeing support programs, and work life balance flexibility. Equal Employment Opportunity Charles River Laboratories is an Equal Opportunity Employer - all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status. If you are interested in applying to Charles River Laboratories and need special assistance or an accommodation due to a disability to complete any forms or to otherwise participate in the resume submission process, please contact a member of our Human Resources team by sending an e-mail message to [email protected]. This contact is for accommodation requests for individuals with disabilities only and cannot be used to inquire about the status of applications. For more information, please visit www.criver.com. 224995

At Charles River, we are passionate about improving the quality of people's lives. When you join our global family, you will help create healthier lives for millions of patients and their families. Charles River employees are innovative thinkers, who are dedicated to continuous learning and improvement. We will empower you with the resources you need to grow and develop in your career. As a Charles River employee, you will be part of an industry-leading, customer-focused company at the forefront of drug development. Your skills will play a key role in bringing life-saving therapies to market faster through simpler, quicker, and more digitalized processes. Whether you are in lab operations, finance, IT, sales, or another area, when you work at Charles River, you will be the difference every day for patients across the globe. **Job Summary** Serve as a method development scientist in the conduct of assigned nonclinical research studies of basic to moderate complexity. ESSENTIAL DUTIES AND RESPONSIBILITIES: * Independently develop new and/or refine bioanalytical methods, followed by successful validation and transfer into Operations. * Partner with other MD Scientists, Principal Investigators, Operations Chemists, and Management to ensure method scope and performance meet the client's requirements. * Assist in assay troubleshooting, with a sense of urgency. * Contribute to the development of novel assays that evolve CRL's current analyte and/or platform offerings. * Consideration of operational efficiency and cost when developing methods. * Provide technical and scientific guidance to the research staff. * Contribute to presentations/posters/manuscripts and attend scientific meetings, conferences and training courses to enhance job and professional skills. * Perform all other related duties as assigned. **Job Qualifications** * **Education:** Bachelor's degree (B.S./B.A.) or equivalent in a scientific related discipline. Related Master's degree (M.S./M.A.) or Ph.D. highly preferred. * **Experience:** Minimum of 6 to 7 years related experience with a Bachelor's degree, 3 to 4 years with a Master's degree, 0 to 2 years with a Ph.D.; in the contract research, academic, or pharmaceutical industries. * An equivalent combination of education and experience may be accepted as a satisfactory substitute for the specific education and experience listed above. * **Certification/Licensure:** None. * **Other:** Hands-on experience with bioanalytical sample extraction techniques and the use of LC-MS/MS instrumentation is required. Understanding of regulatory requirements of study types assigned, as well as Testing Facility SOPs and the Good Laboratory Practices (GLPs), as appropriate. Effective written and verbal communication skills. Ability to handle multiple projects, prioritize work and meet deadlines. Proficiency in the use of standard software including Microsoft Excel, Word, Powerpoint, etc. and with standard laboratory calculations. Compensation Data The pay range for this position is $85,000 - $95,000 USD. Please note that salaries vary within the range based on factors including, but not limited to, experience, skills, education, certifications, and location. **About Safety Assessment** Charles River is committed to helping our partners expedite their preclinical drug development with exceptional safety assessment services, state-of-the-art facilities and expert regulatory guidance. From individual specialty toxicology and IND enabling studies to tailored packages and total laboratory support, our deeply experienced team can design and execute programs that anticipate challenges and avoid roadblocks for a smooth, efficient journey to market. Each year approximately 120 investigational new drug (IND) programs are conducted in our Safety Assessment facilities. **About Charles River** Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients' clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market. With over 20,000 employees within 110 facilities in over 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client's unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. At Charles River, we are passionate about our role in improving the quality of people's lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly worked on 80% of the drugs approved by the U.S. Food and Drug Administration (FDA) in the past five years. We're committed to providing benefits that elevate your quality of life. Based on your position these may include: bonus/incentives based on performance, 401K, paid time off, stock purchase program, Health and wellness coverage, employee and family wellbeing support programs, and work life balance flexibility. **Equal Employment Opportunity** Charles River Laboratories is an Equal Opportunity Employer - all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status. If you are interested in applying to Charles River Laboratories and need special assistance or an accommodation due to a disability to complete any forms or to otherwise participate in the resume submission process, please contact a member of our Human Resources team by sending an e-mail message to crrecruitment_US@crl.com. This contact is for accommodation requests for individuals with disabilities only and cannot be used to inquire about the status of applications. For more information, please visit www.criver.com. 224782

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Research Scientist I Method DevelopmentNovember 22, 2024

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Research Scientist I Method DevelopmentNovember 11, 2024