University Overview The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks among the top 10 universities in the annual U.S. News & World Report survey. Penn has 12 highly-regarded schools that provide opportunities for undergraduate, graduate and continuing education, all influenced by Penn's distinctive interdisciplinary approach to scholarship and learning. As an employer Penn has been ranked nationally on many occasions with the most recent award from Forbes who named Penn one of America's Best Large Employers in 2023. Penn offers a unique working environment within the city of Philadelphia. The University is situated on a beautiful urban campus, with easy access to a range of educational, cultural, and recreational activities. With its historical significance and landmarks, lively cultural offerings, and wide variety of atmospheres, Philadelphia is the perfect place to call home for work and play. The University offers a competitive benefits package that includes excellent healthcare and tuition benefits for employees and their families, generous retirement benefits, a wide variety of professional development opportunities, supportive work and family benefits, a wealth of health and wellness programs and resources, and much more. Posted Job Title Computational Research Scientist and Manager - Cremins Lab Job Profile Title Manager Research Project A Job Description Summary The Cremins lab works at the spatial biology-technology interface to understand chromatin-to-synapse communication during neural circuit activation in the mammalian brain. We aim to understand how chromatin works through long-range physical folding mechanisms to encode neuronal specification and long-term synaptic plasticity in healthy and diseased neural circuits. We pursue a multi-disciplinary approach integrating data across biological scales in the brain, including molecular Chromosome-Conformation-Capture sequencing technologies, single-cell imaging, optogenetics, genome engineering, induced pluripotent stem cell differentiation to neurons/organoids, and in vitro and in vivo electrophysiological measurements. Our long-term scientific goal is to dissect the fundamental mechanisms by which chromatin architecture causally governs genome function and, ultimately, long-term synaptic plasticity and neural circuit features in healthy mammalian brains as well as during the onset and progression of neurodegenerative and neurodevelopmental disease states. Our long-term mentorship goal is to develop a diverse cohort of next-generation scientific thinkers and leaders cross-trained in molecular and computational approaches. We seek to create a positive, high-energy environment with open and honest communication to empower individuals to discover and refine their purpose and grow into the best versions of themselves. The Computational Research Scientist and Project Manager in the Cremins Lab will be responsible for both specific research projects as well as the oversight of the computational infrastructure and computational code and data analysis standards for the laboratory. Job Description Job Responsibilities <ul><li>Take a leadership role in building an in-house computational cluster with backup servers in a second location to facilitate movement of all the lab's data off the cluster and onto local storage for substantial cost savings for the lab.</li><li>With mentoring from the Principal Investigator, oversee and develop algorithms for analyzing ensemble genomics data, single cell genomics data, single cell merFISH and sequential oligopaints imaging data, as well as novel molecular connectomics data.</li><li>Develop code and data sharing standards for the lab, and create SOPs for interfacing with GEO and bitbucket.</li><li>Train the laboratory on code backup in bitbucket and computational lab notebooks.</li><li>Along with the PI, co-lead specific complex interdisciplinary neuroscience projects and spearhead algorithm development for the creative areas of their choice within the lab.</li><li>After the building of infrastructure, ample opportunities for creative advances, grant writing, and drafting/editing manuscripts will be available.</li><li>Oversee the day-to-day management of a subset of computational endeavors of the lab. Oversee 1-4 junior analysts to ensure all sequencing and imaging data is housed, formatted, and stored on the computational cluster (and their own in-house servers) according to Cremins lab protocols.</li></ul> Qualifications Master's or PhD degree preferred with 3-5 years of related experience or an equivalent combination of education and experience. Experienced in python and R and in using Linux/Unix. Familiar with genomics assays and their computational pipelines. Familiar with image processing (segmentation, spot calling, drift correction). Job Location - City, State Philadelphia, Pennsylvania Department / School School of Engineering and Applied Science Pay Range $51,824.00 - $72,000.00 Annual Rate Salary offers are made based on the candidate's qualifications, experience, skills, and education as they directly relate to the requirements of the position, as well as internal and market factors and grade profile. Affirmative Action Statement Penn adheres to a policy that prohibits discrimination on the basis of race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status, or any other legally protected class. Special Requirements Background check required after a conditional job offer is made. Consideration of the background check will be tailored to the requirements of the job. University Benefits <ul><li>Health, Life, and Flexible Spending Accounts: Penn offers comprehensive medical, prescription, behavioral health, dental, vision, and life insurance benefits to protect you and your family's health and welfare. You can also use flexible spending accounts to pay for eligible health care and dependent care expenses with pre-tax dollars.</li><li>Tuition: Take advantage of Penn's exceptional tuition benefits. You, your spouse, and your dependent children can get tuition assistance here at Penn. Your dependent children are also eligible for tuition assistance at other institutions.</li><li>Retirement: Penn offers generous retirement plans to help you save for your future. Penn's Basic, Matching, and Supplemental retirement plans allow you to save for retirement on a pre-tax or Roth basis. Choose from a wide variety of investment options through TIAA and Vanguard.</li><li>Time Away from Work: Penn provides you with a substantial amount of time away from work during the course of the year. This allows you to relax, take vacations, attend to personal affairs, recover from illness or injury, spend time with family-whatever your personal needs may be.</li><li>Long-Term Care Insurance: In partnership with Genworth Financial, Penn offers faculty and staff (and your eligible family members) long-term care insurance to help you cover some of the costs of long-term care services received at home, in the community or in a nursing facility. If you apply when you're newly hired, you won't have to provide proof of good health or be subject to underwriting requirements. Eligible family members must always provide proof of good health and are subject to underwriting.</li><li>Wellness and Work-life Resources: Penn is committed to supporting our faculty and staff as they balance the competing demands of work and personal life. That's why we offer a wide variety of programs and resources to help you care for your health, your family, and your work-life balance.</li><li>Professional and Personal Development: Penn provides an array of resources to help you advance yourself personally and professionally.</li><li>University Resources: As a member of the Penn community, you have access to a wide range of University resources as well as cultural and recreational activities. Take advantage of the University's libraries and athletic facilities, or visit our arboretum and art galleries. There's always something going on at Penn, whether it's a new exhibit at the Penn Museum, the latest music or theater presentation at the Annenberg Center, or the Penn Relays at Franklin Field to name just a few examples. As a member of the Penn community, you're right in the middle of the excitement-and you and your family can enjoy many of these activities for free.</li><li>Discounts and Special Services: From arts and entertainment to transportation and mortgages, you'll find great deals for University faculty and staff. Not only do Penn arts and cultural centers and museums offer free and discounted admission and memberships to faculty and staff. You can also enjoy substantial savings on other goods and services such as new cars from Ford and General Motors, cellular phone service plans, movie tickets, and admission to theme parks.</li><li>Flexible Work Hours: Flexible work options offer creative approaches for completing work while promoting balance between work and personal commitments. These approaches involve use of non-traditional work hours, locations, and/or job structures.</li><li>Penn Home Ownership Services: Penn offers a forgivable loan for eligible employees interested in buying a home or currently residing in West Philadelphia, which can be used for closing costs or home improvements.</li><li>Adoption Assistance: Penn will reimburse eligible employees on qualified expenses in connection with the legal adoption of an eligible child, such as travel or court fees, for up to two adoptions in your household.</li></ul> To learn more, please visit: https://www.hr.upenn.edu/PennHR/benefits-pay

SHIFT:Rotating (United States of America)Seeking Breakthrough Makers Children's Hospital of Philadelphia (CHOP) offers countless ways to change lives. Our diverse community of more than 20,000 Breakthrough Makers will inspire you to pursue passions, develop expertise, and drive innovation. At CHOP, your experience is valued; your voice is heard; and your contributions make a difference for patients and families. Join us as we build on our promise to advance pediatric care-and your career. CHOP's Commitment to Diversity, Equity, and Inclusion CHOP is committed to building an inclusive culture where employees feel a sense of belonging, connection, and community within their workplace. We are a team dedicated to fostering an environment that allows for all to be their authentic selves. We are focused on attracting, cultivating, and retaining diverse talent who can help us deliver on our mission to be a world leader in the advancement of healthcare for children. We strongly encourage all candidates of diverse backgrounds and lived experiences to apply. A Brief OverviewThis Research Assistant position is with the Center for Fetal Research in the Flake Lab <a href="http://www.chop.edu/doctors/flake-alan-w" target="_blank">http://www.chop.edu/doctors/flake-alan-w</a> at the Children's Hospital of Philadelphia. The Flake lab is currently working on an extrauterine system that supports extremely premature neonates. This novel technology offers the possibility of improving outcomes in a patient population with a high rate of mortality and morbidity. The successful candidate will support ongoing research in the lab by functioning as an independent practitioner providing intensive and critical care in an animal NICU. This does not require prior experience and the candidate will be extensively trained in all relevant job functions. The Research Assistant will also be responsible for other tasks including aseptic scrub and surgical technique, post-mortem examinations, etc. This laboratory is a highly collaborative and supportive training environment in which successful candidates will be given the opportunity to directly contribute to projects, potentially resulting in authorship on scientific manuscripts.Recent medical or nursing school graduates and those seeking experience before applying to the Match cycle/residency programs are encouraged to apply. While some laboratory experience is preferred, qualified candidates with a medically relevant licensure degree (RN, NP, PA, MD) will be strongly considered. What you will do<ul><li>Assists faculty in the conduct of research of significant value in the basic and/or translational science area</li><li>Plans, conducts research projects within the federal, institutional regulations and policies</li><li>Collaborates with researchers, external agencies and institutions to develop cooperative research initiatives</li><li>Trains technical staff, students in lab procedures</li><li>Reviews manuscripts for peer-reviewed journals</li><li>Assists with the submission of grant applications, contracts and research projects funding</li><li>Participates in free discussion, research progress, and overall morale</li><li>Responsible for appropriate use of research funds</li><li>May supervise students or other research staff as assigned</li></ul>Education Qualifications<ul><li>Bachelor's Degree Required</li><li>Master's Degree Preferred</li><li>Doctorate Preferred</li></ul>Experience Qualifications<ul><li>At least seven (7) years of directly relevant post grad scientific lab experience Required</li><li>At least nine (9) years of directly relevant post grad scientific lab experience Preferred</li><li>Successful completion of a Post Doc Fellowship Preferred</li></ul>Skills and Abilities<ul><li>Expert knowledge in the use of a wide variety of lab techniques, research equipment and research related software</li><li>Excellent verbal and written communications skills</li><li>Excellent organizational skills</li><li>Excellent critical thinking / problem-solving skills</li><li>Excellent analytical skills</li><li>Solid interpersonal skills</li><li>Basic leadership skills</li></ul> To carry out its mission, CHOP is committed to supporting the health of our patients, families, workforce, and global community. As a condition of employment, CHOP employees who work in patient care buildings or who have patient facing responsibilities must be fully vaccinated against COVID-19 and receive an annual influenza vaccine. <a href="https://careers.chop.edu/us/en/how-we-hire" target="_blank">Learn more.</a> Employees may request exemptions for valid religious and medical reasons. Start dates may be delayed until candidates are immunized or exemption requests are reviewed. <a href="https://careers.chop.edu/us/en/eeo" target="_blank">EEO / VEVRAA Federal Contractor</a> | <a href="https://careers.chop.edu/us/en/tobacco-statement" target="_blank"> Tobacco Statement </a>

Grade: T26 The link below will give you information about the University's "T" salary structure. Learn more about the "T" salary structure A variety of important factors are reviewed by HR when considering salary, including job duties, the applicant's education and experience, all relevant internal equity considerations, department budget, and funding source. The Simon Lab, located within the Department of Cardiovascular Sciences, is looking for a suitably qualified, highly motivated person to work as Research Scientist within our growing translational research group. The Research Scientist will broadly contribute to the scientific endeavors of our diverse and innovative lab, as well as play a key role in leading our research related to integrated redox signaling dynamics and calcium handling in the healthy and diseased heart. For more information about our lab and the cutting-edge research we do, please visit our website at www.thesimonlab.com .. As a senior member of the lab, the Research Scientist is expected to work collaboratively with Dr. Simon to lead and advance key avenues of the group's research program. Typical responsibilities include: project planning and organization; independent research study design, experimentation, data analysis and results interpretation; shared management of mouse colonies, novel transgenic model development and cardiac disease phenotyping; manuscript preparation; critical evaluation of the literature; establishment and adaptation of new methodologies related to redox proteomics, protein-protein interactions, and intracellular organelle crosstalk and functionPerforms other duties as assigned. Required Education & Experience: Ph.D. in physiology, cell biology or other related field and have 4 years of postdoctoral experience within the cardiovascular field or a Master's degree and 5 years of experience. An equivalent combination of education and experience may be considered. Required Skills & Abilities: •Demonstrated ability to work with laboratory animals, particularly as it relates to phenotyping murine models of cardiac stress and disease. •Demonstrated proficiency in murine adult cardiomyocyte isolation and/or Langendorff perfusion models, proteomics, basic bioinformatics, high-resolution and/or live-cell imaging, western blotting, polymerase chain reaction (PCR), molecular cloning, and cell culture techniques. •Ability to use and understand the appropriate statistical software programs (e.g., R, GraphPad Prism), as well as Microsoft Office and other research-based software tools such as EndNote, LabArchives, Snapgene, etc. •Demonstrated ability to work independently and complete experiments in a timely manner. •Excellent research track record, including first-author/joint-first-author publications in reputable peer-reviewed journals. •Excellent technical and analytical skills •Ability to work in a team environment and supervise trainees. Preferred: Ph.D. This is a grant funded position. Temple University is committed to a policy of equal opportunity for all in every aspect of its operations, including employment, service, and educational programs. The University has pledged not to discriminate on the basis of age, color, disability, marital status, national origin or ethnic origin, race, religion, sex (including pregnancy), sexual orientation, gender identity, genetic information or veteran status. Compliance Statement: In the performance of their functions as detailed in the position description employees have an obligation to avoid ethical, legal, financial and other conflicts of interest to ensure that their actions and outside activities do not conflict with their primary employment responsibilities at the institution. Employees are also expected to understand and be in compliance with applicable laws, University and employment policies and regulations, including NCAA regulations for areas and departments which their essential functions cause them to interact. Temple University's Annual Security and Fire Safety Report contains statistics, policies, and procedures related to campus safety. Click here . You may request a copy of the report by calling Temple University's Campus Safety Services at 215-204-7900.

Research Scientist Jobs in Philadelphia, PA

Computational Research Scientist And Manager Cremins Lab
April 12, 2024

Research Scientist 1 Center For Fetal Researchflake Laboratory
March 31, 2024

Research Scientist
March 21, 2024

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Research Scientist Jobs in Philadelphia, PA

Computational Research Scientist And Manager Cremins LabApril 12, 2024

Research Scientist 1 Center For Fetal Researchflake LaboratoryMarch 31, 2024

Research ScientistMarch 21, 2024

Quick filters

Top companies

Computational Research Scientist And Manager Cremins Lab
April 12, 2024

Research Scientist 1 Center For Fetal Researchflake Laboratory
March 31, 2024

Research Scientist
March 21, 2024