Company BackgroundAltis Biosystems has commercialized a patented stem cell platform, recreating the small and large human intestinal epithelium for in vitro, pre-clinical compound screening. Our platform is designed to reduce the cost and time of drug discovery by producing more accurate and reproducible data for better clinical trial performance of novel therapeutics and reducing the need for animal testing. Altis sells its platform as a service or as a product to pharmaceutical companies to support drug discovery including pharmacology, DMPK, and toxicology testing. Additionally, Altis maintains a robust R&D effort dedicated to establishing cutting-edge experimental systems to interrogate disease pathophysiology and broadly support commercial development. Job Title: Research Scientist I, Project Lead Job Type: Full Time Position Summary:Altis Biosystems, Inc. is seeking a full-time Research Scientist I, Project Lead with a strong background in epithelial biology to join our collaborative scientific team.  This position involves designing and conducting research using Altis’ advanced cell-based intestinal models for client projects. The role requires a creative, self-motivated professional with excellent communication, organizational, and analytical skills. Strong capabilities in prioritizing multiple tasks, meeting deadlines, and problem-solving are essential. Proficiency in cell culture with primary cells, biological assays, data analysis, and scientific writing is required. The ability to clearly present results to colleagues and clients is essential. This role also involves collaboration with the Product Development and R&D teams on advancing current models and developing future models to use in the drug development pipelines. The applicant will have an advanced degree in Cell Biology, Biochemistry, or a related scientific discipline, and have a minimum of five years of experience in academia or industry. The ideal candidate will have a current knowledge of gut biology and/or drug metabolism and pharmacokinetics with a track record of relevant publications, direct experience with diverse experimental techniques, and experience with primary mammalian cell culture.  Key Responsibilities:·        Collaborate with clients and the internal team to design and execute research studies·        Manage client projects, including experimental design, lab work, and data analysis·        Prepare and present detailed reports summarizing study outcomes to clients·        Assist with development of novel assays and models of gastrointestinal inflammatory diseases·        Execute common biological assays (e.g., ELISA, qRT-PCR, IF microscopy)·        Assist with laboratory management and maintenance Qualifications:·        Master’s +3 years or PhD in Cell Biology, Biochemistry, or related scientific discipline and experience·        Minimum 2 years of industry experience preferred·        Expertise in in vitro cell culture, especially with primary cells·        Proficiency in molecular biology assays and statistical software (e.g., GraphPad Prism)·        Proficient in the use of Microsoft Word, Excel, and PowerPoint·        Strong communication and interpersonal skills·        Experience supervising and mentoring junior team members·        Experience with project management software (e.g. Wrike) preferred

School of Medicine Established in 1930, Duke University School of Medicine is the youngest of the nation's top medical schools. Ranked sixth among medical schools in the nation, the School takes pride in being an inclusive community of outstanding learners, investigators, clinicians, and staff where interdisciplinary collaboration is embraced and great ideas accelerate translation of fundamental scientific discoveries to improve human health locally and around the globe. Composed of more than 2,600 faculty physicians and researchers, nearly 2,000 students, and more than 6,200 staff, the Duke University School of Medicine along with the Duke University School of Nursing, and Duke University Health System comprise Duke Health, a world-class academic medical center. The Health System encompasses Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Duke Health Integrated Practice, Duke Primary Care, Duke Home Care and Hospice, Duke Health and Wellness, and multiple affiliations. The Duke Toxicology Program at the Occupational and Environmental Medicine Division (OEM) provides toxicological evaluations and risk assessments for potentially hazardous substances in consumer and commercial arts and craft product formulations. Evaluations include an assessment for regulatory compliance against federal, state, and international laws regulating consumer product hazard labeling and worker hazard communication. In addition to expert toxicological judgment, the evaluation process includes the application of a Toxicology Data Base Management System (DMS). The DMS is an internally-developed computerized expert system that applies toxicological risk assessment paradigms to produce confidential reports to clients. The DMS requires accurate input of qualitative and quantitative product information. Constituent data are acquired from laboratory analytical reports, published articles, proprietary research, and regulatory sources. The staff that supports the program require specific skill sets and the ability to work with the DMS. JOB RESPONSIBILITIES: The Research Scientist will learn using the DMS to review and evaluate product formulations and technical materials. This activity requires training in order to provide toxicological assessment of consumer products in accordance with US Federal consumer product regulations such as FHSA/LHAMA/CPSA, Canadian Consumer Product regulations, and specific European Union consumer product regulations. More specifically: <ul> <li>Learn to utilize the DMS for evaluating and interpreting chemical formulations and product descriptions.</li> <li>Convert and use information regarding analytical concentration data.</li> <li>Learn to utilize information provided in research reports regarding toxicological evaluations and risk assessments.</li> <li>Learn to use a risk assessment approach for toxicological evaluations and establishing threshold levels for exposure.</li> <li>Maintain confidentiality regarding topics of proprietary origin and impact.</li> <li>Learn to utilize the computer data management system effectively.</li> <li>Communicate effectively and amicably with group members, data suppliers and clients.</li> <li>Establish professional interaction with several consumer product certifying organizations including their staff, technical committees and boards of directors.</li> <li>Interact in an efficient manner with toxicology, technical, and administrative staff.</li></ul> MINIUMUM REQUIREMENTS OF POSITION: Education: Ph.D. in Toxicology, Chemistry, Biochemistry, Physiology or a related field. Experience: <ul> <li>This is an entry level position for an Early Career Ph.D. toxicologist</li> <li>Will consider a recent Ph.D. graduate with no postdoctoral experience, but some post-doctoral experience is preferred, particularly in applied toxicology, new approach toxicity-testing methodologies, dose-response analysis, and human health chemical risk assessment</li> <li>Experience in the application of new computational toxicology methods for evaluating product safety</li> <li>Experience with working in a technical/administrative team environment is a plus.</li></ul> Skills and Knowledge: <ul> <li>Knowledge of toxicological principles and mechanisms (chemical and biological), dose determinants, and laboratory testing methods.</li></ul> Duke is an Affirmative Action/Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex, sexual orientation, or veteran status. Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas-an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values. Essential Physical Job Functions: Certain jobs at Duke University and Duke University Health System may include essentialjob functions that require specific physical and/or mental abilities. Additional information and provision for requests for reasonable accommodation will be provided by each hiring department.

Research Scientist – OncologyLocation: Full-time | Durham, NC Are you passionate about leveraging molecular biology expertise to advance cancer research? Our client, an innovative oncology-focused organization, is seeking a skilled Research Scientist to join their lab. This role offers the opportunity to make a meaningful impact through cutting-edge molecular profiling and pharmacology studies. About the Role:As a Research Scientist, you’ll lead the design, execution, and interpretation of molecular profiling studies to evaluate mechanisms of action, pharmacology, and efficacy of novel cancer therapies. Your contributions will include developing and implementing profiling analyses and conducting pharmacology studies within a collaborative and dynamic lab environment. Key Responsibilities:<ul><li>Molecular Profiling: Design and execute next-generation sequencing studies to explore mechanisms of action and therapy efficacy.</li><li>Pharmacology Studies: Implement in-house profiling and routine pharmacology/oncology assays.</li><li>Data Analysis: Apply statistical and computational tools (Excel, JMP, R) for data analysis and interpretation.</li><li>Bioinformatics: Utilize programming skills (Python, PERL) to analyze omics datasets and interpret complex sequencing results.</li><li>Project Leadership: Conduct both in-house and outsourced studies, ensuring scientific rigor and reproducibility.</li><li>Communication: Present findings internally and externally; support the development of conference abstracts and manuscripts.</li><li>Operational Excellence: Maintain robust data documentation, operational protocols, and troubleshooting procedures.</li></ul> What You’ll Bring:<ul><li>Education: Ph.D. in molecular biology or a related field, or a master’s degree with significant and relevant experience.</li><li>Experience: At least 5 years of bench research in oncology or a related field.</li><li>Technical Proficiency: Expertise in oncology/pharmacology assays, bioinformatics, and statistical testing.</li><li>Analytical Skills: Adept with tools like Excel, JMP, R, and programming environments.</li></ul> Why Consider This Opportunity?<ul><li>Innovative Environment: Work at the cutting edge of oncology research with a team dedicated to transforming cancer care.</li><li>Career Impact: Contribute to meaningful advancements in therapy development.</li><li>Professional Development: Opportunities for publication and presentation at industry-leading events.</li></ul>

Research Scientist Jobs in Durham, NC

Research Scientist I Project Lead
January 3, 2025

Research Scientist For Hire Only
December 22, 2024

Research Scientist
December 21, 2024

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Research Scientist Jobs in Durham, NC

Research Scientist I Project LeadJanuary 3, 2025

Research Scientist For Hire OnlyDecember 22, 2024

Research ScientistDecember 21, 2024

Quick filters

Top companies

Research Scientist I Project Lead
January 3, 2025

Research Scientist For Hire Only
December 22, 2024

Research Scientist
December 21, 2024